Sarcoma immunotherapy: Past approaches and future directions Journal Article


Authors: D'Angelo, S. P.; Tap, W. D.; Schwartz, G. K.; Carvajal, R. D.
Article Title: Sarcoma immunotherapy: Past approaches and future directions
Abstract: Sarcomas are heterogeneous malignant tumors of mesenchymal origin characterized by more than 100 distinct subtypes. Unfortunately, 25-50% of patients treated with initial curative intent will develop metastatic disease. In the metastatic setting, chemotherapy rarely leads to complete and durable responses; therefore, there is a dire need for more effective therapies. Exploring immunotherapeutic strategies may be warranted. In the past, agents that stimulate the immune system such as interferon and interleukin-2 have been explored and there has been evidence of some clinical activity in selected patients. In addition, many cancer vaccines have been explored with suggestion of benefit in some patients. Building on the advancements made in other solid tumors as well as a better understanding of cancer immunology provides hope for the development of new and exciting therapies in the treatment of sarcoma. There remains promise with immunologic checkpoint blockade antibodies. Further, building on the success of autologous cell transfer in hematologic malignancies, designing chimeric antigen receptors that target antigens that are over-expressed in sarcoma provides a great deal of optimism. Exploring these avenues has the potential to make immunotherapy a real therapeutic option in this orphan disease. © 2014 S. P. D'Angelo et al.
Journal Title: Sarcoma
Volume: 2014
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2014-03-20
Start Page: 391967
Language: English
DOI: 10.1155/2014/391967
PROVIDER: scopus
PMCID: PMC3981453
PUBMED: 24778572
DOI/URL:
Notes: Erratum/Corrigendum issued, see PMID: 26180507 and DOI: 10.1155/2015/259817 -- Export Date: 1 May 2014 -- CODEN: SARCF -- Source: Scopus
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MSK Authors
  1. Gary Schwartz
    370 Schwartz
  2. Richard D Carvajal
    133 Carvajal
  3. Sandra Pierina D'Angelo
    103 D'Angelo
  4. William Douglas Tap
    137 Tap
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