The role of immunotherapy in the management of soft tissue sarcomas: Current landscape and future outlook Review
| Authors: | Banks, L. B.; D'Angelo, S. P. |
| Review Title: | The role of immunotherapy in the management of soft tissue sarcomas: Current landscape and future outlook |
| Abstract: | Soft tissue sarcomas (STS) are a subset of sarcoma, a rare group of heterogeneous malignancies of mesenchymal origin. Current standard of care involves surgical resection with systemic chemotherapy used to treat high-risk localized and metastatic disease. Though classically thought to be immunologically quiet tumors, STS interact with the immune system, undergoing immunoediting that alters tumor immunogenicity and the tumor microenvironment. Recent advances with immune checkpoint inhibition have led to clinical trials exploring the efficacy of immunotherapy in treating STS. Results from these trials point to histologic subtype-specific clinical activity of immune checkpoint blockade. In addition, combinatorial strategies adding immune checkpoint inhibition to local or systemic therapies for STS have further increased their efficacy. Targeted immunotherapies using engineered T-cell receptor-based approaches also show increasing promise as treatment options for some patients with STS. Adoptive transfer of autologous T cells targeting NY-ESO-1 and MAGE-A4 have high response rates in sarcomas expressing these antigens, although recurrence is often seen in responding patients. Future work must focus on identifying primary and acquired mechanisms of resistance to these therapies, and extend T-cell receptor discovery to other tumor-associated antigens. |
| Keywords: | pathology; tumor antigen; sarcoma; immunotherapy; antigens, neoplasm; receptors, antigen, t-cell; immunologic factors; lymphocyte antigen receptor; soft tissue neoplasms; soft tissue tumor; immunologic factor; tumor microenvironment; procedures; humans; human; immune checkpoint inhibitors |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 20 |
| Issue: | 7 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2022-07-01 |
| Start Page: | 834 |
| End Page: | 844 |
| Language: | English |
| DOI: | 10.6004/jnccn.2022.7027 |
| PUBMED: | 35830892 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2022 -- Source: Scopus |
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