| Abstract: |
For the past fifteen years we have studied the secondary metabolites of extremophilic fungi from the Berkeley Pit, an abandoned acid mine waste lake. Fungi associated with an acid-tolerant alga have also been harvested from the Pit. Penicillium clavigerum Demelius was isolated from the green alga Chlorella vulgaris Beyerinck [Beijerinck]. In culture it produced the known compounds phomfuranone (1), patulin (2), dimethylphthalides (3 ) and (4 ), phomopsolide A (5), phomopsolide C (6), phomopsolide B (7), phomopsolide E (8), phomopsolide F (9 ), and phompyrone (10) and the new compound berkbenzofuran thioester (11 ). Compounds 5 and 6 were potent inhibitors (IC50 < 10 μM) of specific and established human cancer cell lines. |
