Azaphilones from an acid mine extremophile strain of a Pleurostomophora sp Journal Article
| Authors: | Stierle, A. A.; Stierle, D. B.; Girtsman, T.; Mou, T. C.; Antczak, C.; Djaballah, H. |
| Article Title: | Azaphilones from an acid mine extremophile strain of a Pleurostomophora sp |
| Abstract: | An extremophilic fungus identified as a Pleurostomophora sp. was isolated from the Berkeley Pit, an acid mine waste lake. When grown in liquid culture, the fungus produced berkchaetoazaphilones A-C (1, 2, and 5), the red pigment berkchaetorubramine (6), and the known compound 4-(hydroxymethyl)quinoline. These compounds were evaluated as inhibitors of matrix metalloproteinase-3, caspase-1, and proinflammatory cytokine production in induced THP-1 cells. Berkchaetoazaphilone B (2) inhibited IL-1β, TNFα, and IL-6 production in the induced inflammasome assay and was cytotoxic toward human retinoblastoma cell line Y79 (IC50 = 1.1 μM), leukemia cell lines CCRF-CEM and SR, and the melanoma cell line LOX IMVI (IC50 = 10 μM). © 2015 The American Chemical Society and American Society of Pharmacognosy. |
| Keywords: | unclassified drug; human cell; antineoplastic agent; interleukin 1beta; cytotoxicity; tumor necrosis factor alpha; interleukin 6; cytokine production; upregulation; fungus; fungus growth; proton nuclear magnetic resonance; leukemia cell line; stromelysin; carbon nuclear magnetic resonance; interleukin 1beta converting enzyme; fungal strain; antiproliferative activity; human; article; retinoblastoma cell line; melanoma cell line; 4 (hydroxymethyl)quinoline; berkchaetoazaphilone a; berkchaetoazaphilone b; berkchaetoazaphilone c; berkchaetorubramine; heteronuclear multiple bond correlation; pleurostomophora |
| Journal Title: | Journal of Natural Products |
| Volume: | 78 |
| Issue: | 12 |
| ISSN: | 0163-3864 |
| Publisher: | American Chemical Society |
| Date Published: | 2015-12-24 |
| Start Page: | 2917 |
| End Page: | 2923 |
| Language: | English |
| DOI: | 10.1021/acs.jnatprod.5b00519 |
| PROVIDER: | scopus |
| PUBMED: | 26641525 |
| PMCID: | PMC5156323 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2016 -- Source: Scopus |
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