Graft-versus-host disease: Regulation by microbe-associated molecules and innate immune receptors Journal Article

  


Authors: Penack, O.; Holler, E.; van den Brink, M. R. M.
Article Title: Graft-versus-host disease: Regulation by microbe-associated molecules and innate immune receptors
Abstract: Acute graft-versus-host disease (GVHD) remains the major obstacle to a more favorable therapeutic outcome of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is characterized by tissue damage in gut, liver, and skin, caused by donor T cells that are critical for antitumor and antimicrobial immunity after HSCT. One obstacle in combating GVHD used to be the lack of understanding the molecular mechanisms that are involved in the initiation phase of this syndrome. Recent research has demonstrated that interactions between microbial-associated molecules (pathogen-associated molecular patterns [PAMPs]) and innate immune receptors (pathogen recognition receptors [PRRs]), such as NOD-like receptors (NLRs) and Toll-like receptors (TLRs), control adaptive immune responses in inflammatory disorders. Polymorphisms of the genes encoding NOD2 and TLR4 are associated with a higher incidence of GVHD in HSC transplant recipients. Interestingly, NOD2 regulates GVHD through its inhibitory effect on antigen-presenting cell (APC) function. These insights identify important mechanisms regarding the induction of GVHD through the interplay of microbial molecules and innate immunity, thus opening a new area for future therapeutic approaches. This review covers current knowledge of the role of PAMPs and PRRs in the control of adaptive immuneresponses during inflammatory diseases, particularly GVHD. © 2010 by The American Society of Hematology.
Keywords: antibiotic agent; unclassified drug; single nucleotide polymorphism; review; nonhuman; pathophysiology; animals; models, biological; nuclear protein; toll like receptor 4; antigen presentation; graft versus host reaction; gene control; innate immunity; immunity, innate; probiotic agent; genetic risk; intestine flora; bone marrow transplantation; graft vs host disease; antibiotic prophylaxis; toll like receptor; caspase recruitment domain protein 15; receptors, immunologic; intestinal mucosa; nucleotide binding oligomerization domain like receptor; pathogen associated molecular pattern; antigens, bacterial
Journal Title: Blood
Volume: 115
Issue: 10
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2010-03-11
Start Page: 1865
End Page: 1872
Language: English
DOI: 10.1182/blood-2009-09-242784
PUBMED: 20042727
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77950471448&partnerID=40&md5=509ce0b83d05b99ac6880aaac5d1ac51
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 20 April 2011" - "CODEN: BLOOA" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Olaf Penack
    20 Penack
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