Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: In vivo and mechanistic studies on the migrastatin core ether analog Journal Article

   


Authors: Oskarsson, T.; Nagorny, P.; Krauss, I. J.; Perez, L.; Mandal, M.; Yang, G.; Ouerfelli, O.; Xiao, D.; Moore, M. A. S.; Massague, J.; Danishefsky, S. J.
Article Title: Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: In vivo and mechanistic studies on the migrastatin core ether analog
Abstract: A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentrationdependent inhibitory effect on migration of breast cancer cells. © 2010 American Chemi cal Society.
Keywords: controlled study; human tissue; unclassified drug; human cell; nonhuman; antineoplastic agents; antineoplastic agent; animal cell; mouse; animals; mice; animal tissue; metastasis; breast cancer; animal experiment; animal model; in vivo study; antineoplastic activity; in vitro study; drug effect; drug screening assays, antitumor; drug synthesis; breast neoplasms; cancer invasion; cancer cell; neoplasm metastasis; cell movement; in-vivo; in-vitro; molecular conformation; total synthesis; inhibitory effect; biological products; migration inhibition; stereoisomerism; growth inhibition; tumor metastasis; natural products; macrolides; piperidones; breast cancer cells; concentration-dependent; mechanistic studies; composite micromechanics; ethers; organic compounds; migrastatin ether
Journal Title: Journal of the American Chemical Society
Volume: 132
Issue: 9
ISSN: 0002-7863
Publisher: American Chemical Society  
Date Published: 2010-03-10
Start Page: 3224
End Page: 3228
Language: English
DOI: 10.1021/ja9101503
PUBMED: 20155906
PROVIDER: scopus
PMCID: PMC2863049
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77949343941&partnerID=40&md5=6460077fd80a0a9b70864a44fb15e3bf
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 20 April 2011" - "CODEN: JACSA" - "Source: Scopus"
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MSK Authors
  1. Mihirbaran Mandal
    8 Mandal
  2. Lucy Perez Fernandez
    3 Perez Fernandez
  3. Danhua Xiao
    2 Xiao
  4. Isaac Krauss
    6 Krauss
  5. Pavel Nagorny
    8 Nagorny
  6. Joan Massague
    388 Massague
  7. Samuel J Danishefsky
    539 Danishefsky
  8. Ouathek Ouerfelli
    100 Ouerfelli
  9. Guangli Yang
    34 Yang
  10. Thordur Oskarsson
    5 Oskarsson
  11. Malcolm A S Moore
    549 Moore
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