Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims Journal Article
| Authors: | Nagorny, P.; Krauss, I.; Njardarson, J. T.; Perez, L.; Gaul, C.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J. |
| Article Title: | Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims |
| Abstract: | In the light of recently disclosed crystallographic studies on migrastatin ketone 2 complex with fascin, the structures of migrastatin ketone 2 and migrastatin ether 4 have been re-evaluated by NMR and X-ray crystallographic techniques. The results of these studies established the correctness of the previously reported structural assignment and confirmed that the 'small molecule' co-crystallized in complex with fascin is not the migrastatin ketone, which was provided for the infusion experiment, but rather its stereoisomer. © 2010 Elsevier Ltd. All rights reserved. |
| Keywords: | unclassified drug; complex formation; drug structure; drug synthesis; nuclear magnetic resonance spectroscopy; crystal structure; natural product; x ray crystallography; fascin; stereoisomerism; migrastatin |
| Journal Title: | Tetrahedron Letters |
| Volume: | 51 |
| Issue: | 30 |
| ISSN: | 0040-4039 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2010-07-28 |
| Start Page: | 3873 |
| End Page: | 3875 |
| Language: | English |
| DOI: | 10.1016/j.tetlet.2010.05.056 |
| PROVIDER: | scopus |
| PMCID: | PMC2910445 |
| PUBMED: | 20676392 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: TELEA" - "Source: Scopus" |
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100Ouerfelli -
34Yang
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