Discovery of potent cell migration inhibitors through total synthesis: Lessons from structure-activity studies of (+)-migrastatin Journal Article
| Authors: | Njardarson, J. T.; Gaul, C.; Shan, D.; Huang, X. Y.; Danishefsky, S. J. |
| Article Title: | Discovery of potent cell migration inhibitors through total synthesis: Lessons from structure-activity studies of (+)-migrastatin |
| Abstract: | Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise total synthesis of migrastatin has allowed us to explore otherwise inaccessible migrastatin-derived structural motifs. This effort has resulted in the discovery of analogues with tumor cell migration inhibitory activity 3 orders of magnitude higher than that of the natural product. Copyright © 2004 American Chemical Society. |
| Keywords: | controlled study; unclassified drug; paclitaxel; animals; mice; steroid; drug structure; drug development; cell line, tumor; drug design; drug synthesis; structure activity relation; structure-activity relationship; wound healing; drug research; endothelium, vascular; cell migration; cell movement; natural product; angiogenesis inhibitors; migration inhibition; lactones; migrastatin; macrolides; piperidones; beta lactam; humans; article; erythronolide derivative |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 126 |
| Issue: | 4 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2004-02-04 |
| Start Page: | 1038 |
| End Page: | 1040 |
| Language: | English |
| DOI: | 10.1021/ja039714a |
| PROVIDER: | scopus |
| PUBMED: | 14746469 |
| DOI/URL: | |
| Notes: | J. Am. Chem. Soc. -- Cited By (since 1996):106 -- Export Date: 16 June 2014 -- CODEN: JACSA -- Source: Scopus |
