NAD+ specificity of bacterial DNA ligase revealed Journal Article
| Author: | Shuman, S. |
| Article Title: | NAD+ specificity of bacterial DNA ligase revealed |
| Abstract: | In this issue of Structure, crystallographic snapshots of a bacterial DNA ligase in complexes with its substrate NAD+ and its product NMN are revealed (Gajiwala and Pinko, 2004). The structures illustrate a novel reaction of DNA ligase and highlight the NMN binding site as a target for new antimicrobials. |
| Keywords: | nonhuman; gene targeting; bacteria (microorganisms); antiinfective agent; amino terminal sequence; escherichia coli; short survey; binding site; crystal structure; protein structure, tertiary; molecular structure; catalysis; conformation; dna binding; polydeoxyribonucleotide synthase; enzyme specificity; enzyme substrate complex; bacterial dna; dna, bacterial; nad; chemical reaction; enzyme synthesis; nicotinamide adenine dinucleotide; dna ligases; adenylation; crystallography; bacteria; priority journal; nicotinamide nucleotide; nicotinamide mononucleotide |
| Journal Title: | Structure |
| Volume: | 12 |
| Issue: | 8 |
| ISSN: | 0969-2126 |
| Publisher: | Cell Press |
| Date Published: | 2004-08-01 |
| Start Page: | 1335 |
| End Page: | 1336 |
| Language: | English |
| DOI: | 10.1016/j.str.2004.07.002 |
| PUBMED: | 15296724 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Cited By (since 1996):3 -- Export Date: 16 June 2014 -- CODEN: STRUE -- Source: Scopus |
