Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming Journal Article

   

Authors:	Samstein, M.; Schreiber, H. A.; Leiner, I. M.; Susac, B.; Glickman, M. S.; Pamer, E. G.
Article Title:	Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming
Abstract:	Defense against infection by Mycobacterium tuberculosis (Mtb) is mediated by CD4 T cells. CCR2+ inflammatory monocytes (IMs) have been implicated in Mtb-specific CD4 T cell responses but their in vivo contribution remains unresolved. Herein, we show that transient ablation of IMs during infection prevents Mtb delivery to pulmonary lymph nodes, reducing CD4 T cell responses. Transfer of MHC class II-expressing IMs to MHC class II-deficient, monocyte-depleted recipients, while restoring Mtb transport to mLNs, does not enable Mtb-specific CD4 T cell priming. On the other hand, transfer of MHC class II-deficient IMs corrects CD4 T cell priming in monocyte-depleted, MHC class II-expressing mice. Specific depletion of classical DCs does not reduce Mtb delivery to pulmonary lymph nodes but markedly reduces CD4 T cell priming. Thus, although IMs acquire characteristics of DCs while delivering Mtb to lymph nodes, cDCs but not moDCs induce proliferation of Mtb-specific CD4 T cells. © Samstein et al.
Journal Title:	eLife
Volume:	2
ISSN:	2050-084X
Publisher:	eLife Sciences Publications Ltd.
Date Published:	2013-11-12
Start Page:	e01086
Language:	English
DOI:	10.7554/eLife.01086.01086
PROVIDER:	scopus
PMCID:	PMC3820971
PUBMED:	24220507
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84887786185&partnerID=40&md5=132dab699d3354d637d5f4705b3f57ad
Notes:	--- - "Export Date: 2 December 2013" - "Source: Scopus"

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