A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo Journal Article
| Authors: | Gallegos, A. M.; van Heijst, J. W. J.; Samstein, M.; Su, X.; Pamer, E. G.; Glickman, M. S. |
| Article Title: | A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo |
| Abstract: | CD4 T cell deficiency or defective IFNγ signaling render humans and mice highly susceptible to Mycobacterium tuberculosis (Mtb) infection. The prevailing model is that Th1 CD4 T cells produce IFNγ to activate bactericidal effector mechanisms of infected macrophages. Here we test this model by directly interrogating the effector functions of Th1 CD4 T cells required to control Mtb in vivo. While Th1 CD4 T cells specific for the Mtb antigen ESAT-6 restrict in vivo Mtb growth, this inhibition is independent of IFNγ or TNF and does not require the perforin or FAS effector pathways. Adoptive transfer of Th17 CD4 T cells specific for ESAT-6 partially inhibited Mtb growth while Th2 CD4 T cells were largely ineffective. These results imply a previously unrecognized IFNγ/TNF independent pathway that efficiently controls Mtb and suggest that optimization of this alternative effector function may provide new therapeutic avenues to combat Mtb through vaccination. © 2011 Gallegos et al. |
| Keywords: | signal transduction; controlled study; nonhuman; mouse; mus; cell growth; animal experiment; animal model; in vivo study; mycobacterium tuberculosis; cellular immunity; gamma interferon; cd4+ t lymphocyte; vaccination; effector cell; th1 cell; tuberculosis; lymphocyte function; tumor necrosis factor; early secretory antigenic target 6 |
| Journal Title: | PLoS Pathogens |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1553-7366 |
| Publisher: | Public Library of Science |
| Date Published: | 2011-05-01 |
| Start Page: | e1002052 |
| Language: | English |
| DOI: | 10.1371/journal.ppat.1002052 |
| PROVIDER: | scopus |
| PMCID: | PMC3098235 |
| PUBMED: | 21625591 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "Art. No.: e1002052" - "Source: Scopus" |
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