Cellular dynamics in the early mouse embryo: From axis formation to gastrulation Journal Article

   


Authors: Nowotschin, S.; Hadjantonakis, A. K.
Article Title: Cellular dynamics in the early mouse embryo: From axis formation to gastrulation
Abstract: Coordinated cell movements and reciprocal tissue interactions direct the formation of the definitive germ layers and the elaboration of the major axes of the mouse embryo. Genetic and embryological studies have defined the major molecular pathways that mediate these morphogenetic processes and provided 'snapshots' of the morphogenetic program. However, it is increasingly clear that this foundation needs to be validated, and can be significantly refined and extended using live imaging approaches. In situ visualization of these processes in living specimens is a major goal, as it provides unprecedented detail of the individual cellular behaviors, which translate into the large-scale tissue rearrangements that shape the embryo. © 2010 Elsevier Ltd.
Keywords: signal transduction; review; nonhuman; animals; mice; cell motion; embryo pattern formation; morphogenesis; cell lineage; cell specificity; extracellular matrix; cell migration; cell movement; cell polarity; embryo, mammalian; cell junction; cell communication; body patterning; embryonic development; endoderm; blastocyst; gastrulation; anterior posterior axis; primitive streak; epithelial mesenchymal transition; intercalation complex; embryo axis; cell encapsulation
Journal Title: Current Opinion in Genetics and Development
Volume: 20
Issue: 4
ISSN: 0959-437X
Publisher: Elsevier Inc.  
Date Published: 2010-08-01
Start Page: 420
End Page: 427
Language: English
DOI: 10.1016/j.gde.2010.05.008
PUBMED: 20566281
PROVIDER: scopus
PMCID: PMC2908213
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77954956275&partnerID=40&md5=ec577aa963428c99b9da83cbd8a8af5d
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: COGDE" - "Source: Scopus"
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MSK Authors
  1. Sonja Nowotschin
    37 Nowotschin
  2. Anna-Katerina Hadjantonakis
    191 Hadjantonakis
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