Other biomarkers for detecting prostate cancer Journal Article
| Authors: | Nogueira, L.; Corradi, R.; Eastham, J. A. |
| Article Title: | Other biomarkers for detecting prostate cancer |
| Abstract: | Prostate-specific antigen (PSA) has been used for detecting prostate cancer since 1994. Although it is the best cancer biomarker available, PSA is not perfect. It lacks both the sensitivity and specificity to accurately detect the presence of prostate cancer. None of the PSA thresholds currently in use consistently identify patients with prostate cancer and exclude patients without cancer. Novel approaches to improve our ability to detect prostate cancer and predict the course of the disease are needed. Additional methods for detecting prostate cancer have been evaluated. Despite the discovery of many new biomarkers, only a few have shown some clinical value. These markers include human kallikrein 2, urokinase-type plasminogen activator receptor, prostate-specific membrane antigen, early prostate cancer antigen, PCA3, α-methylacyl-CoA racemase and glutathione S-transferase φ hypermethylation. We review the reports on biomarkers for prostate cancer detection, and their possible role in the clinical practice. © 2009 BJU International. |
| Keywords: | unclassified drug; cancer diagnosis; diagnostic accuracy; sensitivity and specificity; clinical practice; biological marker; prostate specific antigen; tumor markers, biological; tumor marker; prostate cancer; prostatic neoplasms; prostate specific membrane antigen; antigen specificity; clinical education; early cancer; psa; prostate biopsy; kallikrein; short survey; 2 methylacyl coenzyme a racemase; urokinase; glutathione transferase p1; prostate biomarkers; kallikrein 2; plasminogen activator |
| Journal Title: | BJU International |
| Volume: | 105 |
| Issue: | 2 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-01-01 |
| Start Page: | 166 |
| End Page: | 169 |
| Language: | English |
| DOI: | 10.1111/j.1464-410X.2009.09088.x |
| PUBMED: | 19930175 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: BJINF" - "Source: Scopus" |
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