Prevention and early detection of prostate cancer Journal Article
| Authors: | Cuzick, J.; Thorat, M. A.; Andriole, G.; Brawley, O. W.; Brown, P. H.; Culig, Z.; Eeles, R. A.; Ford, L. G.; Hamdy, F. C.; Holmberg, L.; Ilic, D.; Key, T. J.; Vecchia, C. L.; Lilja, H.; Marberger, M.; Meyskens, F. L.; Minasian, L. M.; Parker, C.; Parnes, H. L.; Perner, S.; Rittenhouse, H.; Schalken, J.; Schmid, H. P.; Schmitz-Dräger, B. J.; Schröder, F. H.; Stenzl, A.; Tombal, B.; Wilt, T. J.; Wolk, A. |
| Article Title: | Prevention and early detection of prostate cancer |
| Abstract: | Prostate cancer is a common malignancy in men and the worldwide burden of this disease is rising. Lifestyle modifications such as smoking cessation, exercise, and weight control offer opportunities to reduce the risk of developing prostate cancer. Early detection of prostate cancer by prostate-specific antigen (PSA) screening is controversial, but changes in the PSA threshold, frequency of screening, and the use of other biomarkers have the potential to minimise the overdiagnosis associated with PSA screening. Several new biomarkers for individuals with raised PSA concentrations or those diagnosed with prostate cancer are likely to identify individuals who can be spared aggressive treatment. Several pharmacological agents such as 5α-reductase inhibitors and aspirin could prevent development of prostate cancer. In this Review, we discuss the present evidence and research questions regarding prevention, early detection of prostate cancer, and management of men either at high risk of prostate cancer or diagnosed with low-grade prostate cancer. |
| Keywords: | immunohistochemistry; survival rate; overall survival; review; cancer risk; prostate specific antigen; protein blood level; cell cycle progression; cancer prevention; genetic association; body weight; cancer screening; smoking cessation; risk assessment; prostate cancer; gleason score; oncogene; diet; fluorescence in situ hybridization; early diagnosis; acetylsalicylic acid; eflornithine; family history; antigen detection; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; finasteride; kallikrein; lycopene; physical activity; high risk population; somatomedin c; dutasteride; lifestyle modification; cyclin d1; steroid 5alpha reductase inhibitor; smad4 protein; osteopontin; sulforaphane; human |
| Journal Title: | Lancet Oncology |
| Volume: | 15 |
| Issue: | 11 |
| ISSN: | 1470-2045 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2014-10-01 |
| Start Page: | e484 |
| End Page: | e492 |
| Language: | English |
| DOI: | 10.1016/s1470-2045(14)70211-6 |
| PROVIDER: | scopus |
| PMCID: | PMC4203149 |
| PUBMED: | 25281467 |
| DOI/URL: | |
| Notes: | Export Date: 1 December 2014 -- Source: Scopus |
