From lipid second messengers to molecular motors: Microtubule-organizing center reorientation in T cells Journal Article
| Authors: | Huse, M.; Le Floc'h, A.; Liu, X. |
| Article Title: | From lipid second messengers to molecular motors: Microtubule-organizing center reorientation in T cells |
| Abstract: | In T lymphocytes, polarization of the microtubule-organizing center (MTOC) to the immunological synapse enables the directional secretion of cytokines, cytolytic factors, and other soluble molecules toward the antigen-presenting cell. This is likely to be crucial for maintaining the specificity of T-cell effector responses. Here, we review recent advances in our understanding of MTOC reorientation in T cells, focusing first on the importance of diacylglycerol and protein kinase C isozymes and then on the molecular motor proteins that function downstream to drive MTOC movement. © 2013 John Wiley & Sons A/S. |
| Keywords: | signal transduction; t cells; signaling proteins; lipid mediators; protein kinases and phosphatases; t-cell receptors |
| Journal Title: | Immunological Reviews |
| Volume: | 256 |
| Issue: | 1 |
| ISSN: | 0105-2896 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2013-11-01 |
| Start Page: | 95 |
| End Page: | 106 |
| Language: | English |
| DOI: | 10.1111/imr.12116 |
| PROVIDER: | scopus |
| PUBMED: | 24117815 |
| PMCID: | PMC4595039 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):2 - "Export Date: 1 November 2013" - "CODEN: IMRED" - "Source: Scopus" |
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