Two-Tiered Control of Epithelial Growth and Autophagy by the Insulin Receptor and the Ret-Like Receptor, Stitcher Journal Article
| Authors: | O'Farrell, F.; Wang, S.; Katheder, N.; Rusten, T. E.; Samakovlis, C. |
| Article Title: | Two-Tiered Control of Epithelial Growth and Autophagy by the Insulin Receptor and the Ret-Like Receptor, Stitcher |
| Abstract: | Body size in Drosophila larvae, like in other animals, is controlled by nutrition. Nutrient restriction leads to catabolic responses in the majority of tissues, but the Drosophila mitotic imaginal discs continue growing. The nature of these differential control mechanisms that spare distinct tissues from starvation are poorly understood. Here, we reveal that the Ret-like receptor tyrosine kinase (RTK), Stitcher (Stit), is required for cell growth and proliferation through the PI3K-I/TORC1 pathway in the Drosophila wing disc. Both Stit and insulin receptor (InR) signaling activate PI3K-I and drive cellular proliferation and tissue growth. However, whereas optimal growth requires signaling from both InR and Stit, catabolic changes manifested by autophagy only occur when both signaling pathways are compromised. The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling. © 2013 O'Farrell et al. |
| Keywords: | signal transduction; controlled study; protein expression; protein phosphorylation; unclassified drug; nonhuman; protein function; protein localization; cell proliferation; cell growth; cell protein; molecular dynamics; drosophila; phosphatidylinositol 3 kinase; growth regulation; epithelium cell; cell count; autophagy; protein determination; bioaccumulation; catabolism; insulin receptor; mammalian target of rapamycin complex 1; rearranged during transfection like receptor tyrosine kinase; stitcher |
| Journal Title: | PLoS Biology |
| Volume: | 11 |
| Issue: | 7 |
| ISSN: | 1544-9173 |
| Publisher: | Public Library of Science |
| Date Published: | 2013-07-01 |
| Start Page: | e1001612 |
| Language: | English |
| DOI: | 10.1371/journal.pbio.1001612 |
| PROVIDER: | scopus |
| PMCID: | PMC3720245 |
| PUBMED: | 23935447 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2013" - "CODEN: PBLIB" - "Source: Scopus" |
