IL-2-dependent adaptive control of NK cell homeostasis Journal Article

   


Authors: Gasteiger, G.; Hemmers, S.; Bos, P. D.; Sun, J. C.; Rudensky, A. Y.
Article Title: IL-2-dependent adaptive control of NK cell homeostasis
Abstract: Activation and expansion of T and B lymphocytes and myeloid cells are controlled by Foxp3+ regulatory T cells (T reg cells), and their deficiency results in a fatal lympho- and myeloproliferative syndrome. A role for T reg cells in the homeostasis of innate lymphocyte lineages remained unknown. Here, we report that T reg cells restrained the expansion of immature CD127+ NK cells, which had the unique ability to up-regulate the IL2Rα (CD25) in response to the proinflammatory cytokine IL-12. In addition, we observed the preferential accumulation of CD127+ NK cells in mice bearing progressing tumors or suffering from chronic viral infection. CD127+ NK cells expanded in an IL-2-dependent manner upon T reg cell depletion and were able to give rise to mature NK cells, indicating that the latter can develop through a CD25+ intermediate stage. Thus, T reg cells restrain the IL-2-dependent CD4+ T cell help for CD127+ immature NK cells. These findings highlight the adaptive control of innate lymphocyte homeostasis. © 2013 Gasteiger et al.
Keywords: controlled study; nonhuman; animal cell; mouse; animals; mice; interleukin 2; animal experiment; mice, inbred c57bl; lymphocyte activation; t-lymphocytes, regulatory; cd4+ t lymphocyte; cd4-positive t-lymphocytes; natural killer cell; killer cells, natural; upregulation; virus infection; cd25+ t lymphocyte; t cell depletion; homeostasis; interleukin 12; interleukin-2; interleukin 2 receptor alpha; interleukin-2 receptor alpha subunit; interleukin-12; interleukin-7 receptor alpha subunit
Journal Title: Journal of Experimental Medicine
Volume: 210
Issue: 6
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 2013-06-03
Start Page: 1179
End Page: 1187
Language: English
DOI: 10.1084/jem.20122571
PROVIDER: scopus
PMCID: PMC3674698
PUBMED: 23650439
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84880674997&partnerID=40&md5=5601a5f3dd99703964471a470e3c3be0
Notes: --- - Cited By (since 1996):2 - "Export Date: 4 September 2013" - "CODEN: JEMEA" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Alexander Rudensky
    156 Rudensky
  2. Paula Daniela Bos
    12 Bos
  3. Joseph C Sun
    131 Sun
  4. Georg Gasteiger
    13 Gasteiger
  5. Saskia Hemmers
    16 Hemmers
Related MSK Work