IL-15: Targeting CD8 + T cells for immunotherapy Journal Article
| Authors: | Diab, A.; Cohen, A. D.; Alpdogan, O.; Perales, M. A. |
| Article Title: | IL-15: Targeting CD8 + T cells for immunotherapy |
| Abstract: | IL-15 is a pleiotropic cytokine that plays an important role in both the innate and adaptive immune system. IL-15 promotes the activation of neutrophils and macrophages, and is critical to DC function. In addition, IL-15 is essential to the development, homeostasis, function and survival of natural killer (NK) cells, NK T (NKT) cells and CD8 + T cells. Based on these properties, IL-15 has been proposed as a useful cytokine for immunotherapy. It is currently being investigated in settings of immune deficiency, for the in vitro expansion of T and NK cells, as well as an adjuvant for vaccines. In this paper we will review the targeting of IL-15 for immunotherapy, with a particular emphasis on its effects on CD8 + T cells. © 2005 ISCT. |
| Keywords: | pathogenesis; review; nonhuman; drug targeting; human immunodeficiency virus infection; protein function; neoplasms; cd8 antigen; t lymphocyte; cd8-positive t-lymphocytes; mouse; animals; cell survival; interleukin 2; cancer immunotherapy; melanoma; cell maturation; dendritic cell; hematopoietic stem cell transplantation; in vitro study; psoriasis; monoclonal antibody; lung metastasis; cytokine; lymphocyte activation; immunotherapy; glioblastoma; graft versus host reaction; natural killer cell; killer cells, natural; malignant neoplastic disease; tumor immunity; autoimmunity; innate immunity; immunological adjuvant; human immunodeficiency virus; rheumatoid arthritis; antiretrovirus agent; highly active antiretroviral therapy; protein structure; tumor; immune deficiency; homeostasis; tumor rejection; influenza vaccine; influenza; adoptive immunotherapy; interleukin 15; vaccine; pleiotropy; hiv infections; vaccines; tetanus toxoid; influenza virus; human t cell leukemia virus; human t cell leukemia virus infection; growth inhibition; tetanus; interleukin-15; macrophage activation; il-15; human immunodeficiency virus vaccine; leukocyte activation; lymphocyte transfer; immune system diseases; interleukin 15 receptor; clostridium tetani |
| Journal Title: | Cytotherapy |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 1465-3249 |
| Publisher: | Elsevier Science Ltd. |
| Date Published: | 2005-01-01 |
| Start Page: | 23 |
| End Page: | 35 |
| Language: | English |
| DOI: | 10.1080/14653240510018037 |
| PUBMED: | 16040381 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 24 October 2012" - "CODEN: CYTRF" - "Source: Scopus" |
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