Skin toxicity of targeted cancer agents: Mechanisms and intervention Journal Article
| Authors: | Belum, V. R.; Fontanilla Patel, H.; Lacouture, M. E.; Rodeck, U. |
| Article Title: | Skin toxicity of targeted cancer agents: Mechanisms and intervention |
| Abstract: | In recent years, targeted agents have rapidly evolved as effective tools in the clinical management of a broad range of malignant diseases. These agents disrupt molecular mechanisms and signaling modules that drive the malignant phenotype in defined subsets of malignancies. Beyond the intended cellular targets crucial to tumor growth and progression, these agents also affect signal transduction in normal cells and tissues. The resulting adverse events and their clinical management continue to change, as newer agents with an ever-increasing target spectrum are developed. We provide a succinct overview of dermatologic toxicities arising from the targeting of receptor tyrosine kinases and downstream effectors. Emergent insights into the pathomechanisms involved and the use of this knowledge base to alleviate cutaneous adverse events are discussed. © 2013 Future Medicine Ltd. |
| Keywords: | signal transduction; mitogen activated protein kinase; review; skin toxicity; antineoplastic agent; neoplasms; disease association; drug eruption; enzyme inhibition; mucosa inflammation; skin cancer; drug effect; keratinocyte; skin carcinoma; nail disease; protein kinase inhibitors; enzyme phosphorylation; acne; etanercept; hair disease; innate immunity; immunomodulation; papule; drug toxicity; receptor protein-tyrosine kinases; egfr; adaptive immunity; braf; mek; skin carcinogenesis; epidermal growth factor receptor kinase inhibitor; interleukin 1; skin abnormalities; b raf kinase inhibitor; pustule; hair follicle; molecular targeted therapy; menadione; vemurafenib; dabrafenib; ras/raf/mek/mapk; targeted agent |
| Journal Title: | Future Oncology |
| Volume: | 9 |
| Issue: | 8 |
| ISSN: | 1479-6694 |
| Publisher: | Future Medicine |
| Date Published: | 2013-08-01 |
| Start Page: | 1161 |
| End Page: | 1170 |
| Language: | English |
| DOI: | 10.2217/fon.13.62 |
| PROVIDER: | scopus |
| PUBMED: | 23902247 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2013" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work