Th17 and regulatory T cells in mediating and restraining inflammation Journal Article
| Authors: | Littman, D. R.; Rudensky, A. Y. |
| Article Title: | Th17 and regulatory T cells in mediating and restraining inflammation |
| Abstract: | The vertebrate immune system is poised in a state of equilibrium that permits accurate and rapid protective responses against pathogens but curtails potential for causing harm to the host through targeting of " self" and provoking overexuberant inflammatory processes. In this Review we discuss this balance achieved in large part by interactions of different classes of T lymphocytes that have potent pro- or anti-inflammatory activity in the context of genetic and environmental factors, particularly the commensal microbiota. © 2010 Elsevier Inc. |
| Keywords: | signal transduction; review; nonhuman; transcription factor foxp3; heredity; immune system; interleukin 13; interleukin 21; interleukin 4; interleukin 5; inflammation; pathology; vertebrata; lymphocyte differentiation; t lymphocyte receptor; immunological tolerance; regulatory t lymphocyte; th2 cell; immunology; immune tolerance; antibiotic resistance; immune response; gamma interferon; t-lymphocytes, regulatory; molecular recognition; cd4+ t lymphocyte; interleukin 6; cytokine production; innate immunity; immunomodulation; antiinflammatory activity; virus infection; interleukin 17; th17 cell; t-lymphocytes, helper-inducer; cd4 antigen; th1 cell; adaptive immunity; microbiology; environmental factor; cell interaction; bacterial infection; clostridium difficile; vertebrate; t lymphocyte subpopulation; interleukin 12; infection sensitivity; listeria monocytogenes; bacterium; helper cell; intestine mucosa; commensal; bacteria; immunoglobulin receptor; interleukin 23; citrobacter rodentium; infection resistance; microflora; intestinal mucosa |
| Journal Title: | Cell |
| Volume: | 140 |
| Issue: | 6 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2010-03-01 |
| Start Page: | 845 |
| End Page: | 858 |
| Language: | English |
| DOI: | 10.1016/j.cell.2010.02.021 |
| PUBMED: | 20303875 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 39" - "Export Date: 20 April 2011" - "CODEN: CELLB" - "Source: Scopus" |
