Subarticular inflammatory pseudoabscesses: A pathologic study with clinical correlation Journal Article


Authors: Zhang, L.; Mirza, S. Z.; DiCarlo, E. F.
Article Title: Subarticular inflammatory pseudoabscesses: A pathologic study with clinical correlation
Abstract: Abnormal accumulation of neutrophils in a subarticular bone usually raises the concern for osteomyelitis or septic arthritis, a disabling and potentially life-threatening medical condition. At the pathology department of a specialized orthopedic institute, we observed a distinct pattern of subarticular inflammation mimicking infection characterized by collections of neutrophils, macrophages, and fibrin in pseudocystic spaces of variable size and extent in the superficial subarticular bone not accompanied by granulation tissue or necrosis. We coined the term "inflammatory pseudoabscess" to describe these accumulations. From 1997-2015, we reported inflammatory pseudoabscesses in 157 primary arthroplasty/osteotomy specimens from 143 patients without penetrating trauma or hardware in the affected joint. The predominant gross and histologic features were those of destructive/inflammatory joint disease, including lymphoplasmacytic synovitis (95.3%), subchondral osseous chronic inflammation (80.3%), exudative synovitis (58.0%), synovial pannus (52.0%), and marginal erosions of articular cartilage and/or subarticular bone (43.3%). Clinical information was available in 137 (95.8%) patients, 107 (overall: 74.8%) of whom had preoperatively or postoperatively diagnosed inflammatory arthropathy, most commonly rheumatoid arthritis. The remaining 30 (overall: 21.0%) patients had no documented inflammatory disorders, but some had bilateral or multijoint arthropathy, hands/feet involvement, lymphoplasmacytic synovitis, ulcerative colitis, or family history of inflammatory arthropathy. There was no documented infection-associated implant failure. We believe that inflammatory pseudoabscess represents an intraosseous manifestation of noninfectious inflammatory disorders of joints. This feature should be recognized by pathologists and used to suggest further clinical evaluation for undiagnosed inflammatory joint diseases. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Keywords: adolescent; adult; child; aged; aged, 80 and over; middle aged; retrospective studies; young adult; diagnosis, differential; differential diagnosis; pathology; retrospective study; biopsy; immunology; neutrophil; bone; predictive value of tests; neutrophils; rheumatoid arthritis; bone and bones; predictive value; joints; abscess; synovitis; joint; arthritis, rheumatoid; very elderly; humans; human; male; female; inflammatory pseudoabscess; joint infection; inflammatory arthropathy
Journal Title: American Journal of Surgical Pathology
Volume: 44
Issue: 5
ISSN: 0147-5185
Publisher: Lippincott Williams & Wilkins  
Date Published: 2020-05-01
Start Page: 633
End Page: 640
Language: English
DOI: 10.1097/pas.0000000000001440
PUBMED: 32294062
PROVIDER: scopus
DOI/URL:
Notes: Conference Paper -- Export Date: 2 November 2020 -- Source: Scopus
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  1. Lingxin Zhang
    8 Zhang