Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain Journal Article
| Authors: | Winter, J. M.; Chiou, G.; Bothwell, I. R.; Xu, W.; Garg, N. K.; Luo, M.; Tang, Y. |
| Article Title: | Expanding the structural diversity of polyketides by exploring the cofactor tolerance of an inline methyltransferase domain |
| Abstract: | A strategy for introducing structural diversity into polyketides by exploiting the promiscuity of an in-line methyltransferase domain in a multidomain polyketide synthase is reported. In vitro investigations using the highly-reducing fungal polyketide synthase CazF revealed that its methyltransferase domain accepts the nonnatural cofactor propargylic Se-adenosyl-l-methionine and can transfer the propargyl moiety onto its growing polyketide chain. This propargylated polyketide product can then be further chain-extended and cyclized to form propargyl-α pyrone or be processed fully into the alkyne-containing 4′-propargyl-chaetoviridin A. © 2013 American Chemical Society. |
| Journal Title: | Organic Letters |
| Volume: | 15 |
| Issue: | 14 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2013-07-01 |
| Start Page: | 3774 |
| End Page: | 3777 |
| Language: | English |
| DOI: | 10.1021/ol401723h |
| PROVIDER: | scopus |
| PUBMED: | 23837609 |
| PMCID: | PMC3779521 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: ORLEF" - "Source: Scopus" |
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