The dimycocerosate ester polyketide virulence factors of mycobacteria Journal Article
| Authors: | Onwueme, K. C.; Vos, C. J.; Zurita, J.; Ferreras, J. A.; Quadri, L. E. N. |
| Article Title: | The dimycocerosate ester polyketide virulence factors of mycobacteria |
| Abstract: | Recent advances in the study of mycobacterial lipids indicate that the class of outer membrane lipids known as dimycocerosate esters (DIMs) are major virulence factors of clinically relevant mycobacteria including Mycobacterium tuberculosis and Mycobacterium leprae. DIMs are a structurally intriguing class of polyketide synthase-derived wax esters discovered over seventy years ago, yet, little was known until recently about their biosynthesis. Availability of several mycobacterial genomes has accelerated progress toward clarifying steps in the DIM biosynthetic pathway and it is our belief that reviewing the bases of our current knowledge will clarify outstanding issues and help direct future endeavors. © 2005 Elsevier Ltd. All rights reserved. |
| Keywords: | antibiotic agent; unclassified drug; genetics; review; nonhuman; comparative study; protein domain; animals; classification; gene function; bacterial virulence; biosynthesis; methyltransferase; mycobacterium tuberculosis; immune response; mycobacterium bovis; glycosylation; bleomycin; mycobacterium haemophilum; crystal structure; oxidative stress; bacterial genome; structure analysis; oxidoreductase; biochemistry; mycobacterium; corynebacterineae; rapamycin; host cell; stereospecificity; mycobacteriosis; stereochemistry; immunosuppressive agent; esters; erythromycin; bacterial gene; ester derivative; mevinolin; synthetase; macrolides; fatty acid derivative; outer membrane protein; virulence factors; mycobacterium leprae; virulence factor; hypocholesterolemic agent; mycobacterium marinum; dimycocerosate ester; dimycocerosate ester polyketide; glycol; polyketide; polyketide synthase; mycobacterium kansasii; mycobacterium ulcerans; polyketide synthases |
| Journal Title: | Progress in Lipid Research |
| Volume: | 44 |
| Issue: | 5 |
| ISSN: | 0163-7827 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Date Published: | 2005-09-01 |
| Start Page: | 259 |
| End Page: | 302 |
| Language: | English |
| DOI: | 10.1016/j.plipres.2005.07.001 |
| PUBMED: | 16115688 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 49" - "Export Date: 24 October 2012" - "CODEN: PLIRD" - "Source: Scopus" |
