A unified synthetic approach to polyketides having both skeletal and stereochemical diversity Journal Article
| Authors: | Shang, S.; Iwadare, H.; Macks, D. E.; Ambrosini, L. M.; Tan, D. S. |
| Article Title: | A unified synthetic approach to polyketides having both skeletal and stereochemical diversity |
| Abstract: | An efficient systematic approach to the diversity-oriented synthesis of polyketides has been developed to provide both skeletal and stereochemical diversity. Each synthetic intermediate is also a desired polyketide fragment and no protecting group manipulations are required. A first-generation synthesis provides a 74-membered polyketide library comprising six different skeletal classes, each in one to five steps from propargylic alcohol precursors. A study of epoxyol opening reactions revealed unusual reactivity trends based on epoxide configuration. © 2007 American Chemical Society. |
| Keywords: | methylation; conference paper; chemistry; chemical structure; molecular structure; macrolide; synthesis; stereoisomerism; carbon; epoxy compounds; macrolides; epoxide |
| Journal Title: | Organic Letters |
| Volume: | 9 |
| Issue: | 10 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2007-05-10 |
| Start Page: | 1895 |
| End Page: | 1898 |
| Language: | English |
| DOI: | 10.1021/ol070405p |
| PUBMED: | 17439132 |
| PROVIDER: | scopus |
| PMCID: | PMC2597797 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 27" - "Export Date: 17 November 2011" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work