An update on clinical trials in the treatment of advanced hepatocellular carcinoma Journal Article
| Authors: | Lee, J. K.; Abou-Alfa, G. K. |
| Article Title: | An update on clinical trials in the treatment of advanced hepatocellular carcinoma |
| Abstract: | Despite the successful FDA approval of sorafenib as the standard of care therapy in patients with advanced hepatocellular carcinoma (HCC), its clinical benefits have been modest. The mortality rate remains high and prognosis poor for patients with advanced-stage HCC. The exact mechanism of sorafenib in the treatment of HCC and its resistance at the molecular levels are largely unknown. There are no other treatment options in first-line therapy and there is currently no standard of care second-line therapies available. Thus, there is a critical need for novel therapeutic approaches for the treatment of advanced HCC, and thus a clear justification for the already reported, currently ongoing, and planned clinical trials. © 2013 by Lippincott Williams & Wilkins. |
| Keywords: | cancer survival; unclassified drug; fatigue; neutropenia; hepatocellular carcinoma; sorafenib; bevacizumab; doxorubicin; erlotinib; placebo; sunitinib; advanced cancer; cancer combination chemotherapy; drug dose reduction; drug efficacy; drug withdrawal; hepatitis b; hypertension; liver cell carcinoma; liver cirrhosis; nonhuman; antineoplastic agents; carcinoma, hepatocellular; clinical trials as topic; liver neoplasms; conference paper; neoplasm staging; progression free survival; thrombocytopenia; cancer mortality; health care quality; liver metastasis; drug therapy, combination; open study; tumor growth; tyrosine kinase inhibitor; antiangiogenic activity; everolimus; clinical trials; vegf; randomized controlled trial (topic); clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); brivanib; multicenter study (topic); c-met; biological agents; cancer prognosis; arginine deiminase; cabozantinib; left ventricular systolic dysfunction; tivantinib; linifanib; ramucirumab; peg 20 |
| Journal Title: | Journal of Clinical Gastroenterology |
| Volume: | 47 |
| Issue: | Suppl.1 |
| ISSN: | 0192-0790 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2013-07-01 |
| Start Page: | S16 |
| End Page: | S19 |
| Language: | English |
| DOI: | 10.1097/MCG.0b013e31827d77a2 |
| PROVIDER: | scopus |
| PUBMED: | 23751800 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: JCGAD" - "Source: Scopus" |
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