Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation Journal Article


Authors: Iyer, N. G.; Kim, L.; Nixon, I. J.; Palmer, F.; Shah, J. P.; Patel, S. G.; Ganly, I.
Article Title: Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation
Abstract: Background Existing treatment regimens for squamous cell carcinoma (SCC) of the base of tongue (BOT) favor chemoradiation. However, there is a shifting paradigm toward minimally invasive surgery with adjuvant radiatiotherapy for select tumors. The aim was to report our experience in conventional surgical management with particular focus on T1/T2 tumors, which may be candidates for minimally invasive techniques. Methods Between 1985 and 2005, 128 patients were treated with primary surgery. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were calculated using Kaplan-Meier method, and predictive factors analyzed by univariate and multivariate analyses. Results Five-year OS, DSS, and RFS rates were 60%, 70%, and 61%, respectively. Multivariate analysis showed pathologic T classification and extracapsular extension (ECE) were significant predictors for DSS, whereas T classification remained significant for local recurrence. DSS for T1/T2 tumors ranged from 77% (node-positive) to 84% (node-negative). Conclusion T classification and ECE are independent predictors of outcome for BOT SCC. Patients with cT1/T2 tumors had excellent outcome and may be suitable for transoral robotic or endoscopic surgical procedures. Copyright © 2012 Wiley Periodicals, Inc.
Keywords: adult; cancer survival; controlled study; aged; cancer surgery; major clinical study; overall survival; multimodality cancer therapy; cancer radiotherapy; postoperative care; lymph node metastasis; cohort analysis; retrospective study; survival time; disease severity; disease specific survival; tongue carcinoma; predictive value; mandible resection; oropharynx; recurrence free survival; extracapsular extension; minimally invasive procedure; hpv; scc; tongue base
Journal Title: Head & Neck
Volume: 35
Issue: 7
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 2013-07-01
Start Page: 999
End Page: 1006
Language: English
DOI: 10.1002/hed.23071
PROVIDER: scopus
PUBMED: 22733709
DOI/URL:
Notes: --- - "Export Date: 1 August 2013" - "CODEN: HEANE" - "Source: Scopus"
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MSK Authors
  1. Snehal G Patel
    342 Patel
  2. Leslie Kim
    3 Kim
  3. Narayanan Gopalakrishna Iyer
    16 Iyer
  4. Iain James Nixon
    60 Nixon
  5. Ian Ganly
    313 Ganly
  6. Jatin P Shah
    643 Shah
  7. Frank Palmer
    82 Palmer