Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation Journal Article

  

Authors:	Iyer, N. G.; Kim, L.; Nixon, I. J.; Palmer, F.; Shah, J. P.; Patel, S. G.; Ganly, I.
Article Title:	Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation
Abstract:	Background Existing treatment regimens for squamous cell carcinoma (SCC) of the base of tongue (BOT) favor chemoradiation. However, there is a shifting paradigm toward minimally invasive surgery with adjuvant radiatiotherapy for select tumors. The aim was to report our experience in conventional surgical management with particular focus on T1/T2 tumors, which may be candidates for minimally invasive techniques. Methods Between 1985 and 2005, 128 patients were treated with primary surgery. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were calculated using Kaplan-Meier method, and predictive factors analyzed by univariate and multivariate analyses. Results Five-year OS, DSS, and RFS rates were 60%, 70%, and 61%, respectively. Multivariate analysis showed pathologic T classification and extracapsular extension (ECE) were significant predictors for DSS, whereas T classification remained significant for local recurrence. DSS for T1/T2 tumors ranged from 77% (node-positive) to 84% (node-negative). Conclusion T classification and ECE are independent predictors of outcome for BOT SCC. Patients with cT1/T2 tumors had excellent outcome and may be suitable for transoral robotic or endoscopic surgical procedures. Copyright © 2012 Wiley Periodicals, Inc.
Keywords:	adult; cancer survival; controlled study; aged; cancer surgery; major clinical study; overall survival; multimodality cancer therapy; cancer radiotherapy; postoperative care; lymph node metastasis; cohort analysis; retrospective study; survival time; disease severity; disease specific survival; tongue carcinoma; predictive value; mandible resection; oropharynx; recurrence free survival; extracapsular extension; minimally invasive procedure; hpv; scc; tongue base
Journal Title:	Head & Neck
Volume:	35
Issue:	7
ISSN:	1043-3074
Publisher:	John Wiley & Sons, Inc.
Date Published:	2013-07-01
Start Page:	999
End Page:	1006
Language:	English
DOI:	10.1002/hed.23071
PROVIDER:	scopus
PUBMED:	22733709
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84879414449&partnerID=40&md5=6cce89fb8ac2c79b41e44670d35858f9
Notes:	--- - "Export Date: 1 August 2013" - "CODEN: HEANE" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/44264