Squamous cell carcinoma of the tonsil managed by conventional surgery and postoperative radiation Journal Article
| Authors: | Rahmati, R.; Dogan, S.; Pyke, O.; Palmer, F.; Awad, M.; Lee, N.; Kraus, D. H.; Shah, J. P.; Patel, S. G.; Ganly, I. |
| Article Title: | Squamous cell carcinoma of the tonsil managed by conventional surgery and postoperative radiation |
| Abstract: | Background The purpose of this study was to report the long-term outcome of patients with squamous cell cancer (SCC) of the tonsil managed by surgery followed by postoperative radiotherapy (PORT). Methods Eighty-eight patients treated between 1985 and 2005 were analyzed. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) were determined by the Kaplan-Meier method. Factors predictive of outcome were determined by univariate and multivariate analysis. Results Forty-eight percent of patients had T3 to T4 disease and 75% had a positive neck. Five-year OS, DSS, and RFS were 66%, 82%, and 80%, respectively. The status of the neck was not predictive of outcome (DSS 80% for N0 vs 82% for N+; p =.97). Lymphovascular invasion was an independent predictor of OS, DSS, and RFS on multivariate analysis. Conclusion Lymphovascular invasion but not pathological stage of the neck is an independent predictor of outcome in patients with tonsillar SCC. © 2014 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer chemotherapy; cancer survival; aged; cancer surgery; major clinical study; overall survival; squamous cell carcinoma; multimodality cancer therapy; cancer patient; cancer radiotherapy; postoperative care; outcome assessment; follow up; antineoplastic agent; retrospective study; prognostic factors; surgery; disease specific survival; tonsil carcinoma; oropharynx; recurrence free survival; tonsil; lymph vessel metastasis; human papillomavirus (hpv); human; male; female; priority journal; article; squamous cell carcinoma (scc) |
| Journal Title: | Head & Neck |
| Volume: | 37 |
| Issue: | 6 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2015-06-01 |
| Start Page: | 800 |
| End Page: | 807 |
| Language: | English |
| DOI: | 10.1002/hed.23679 |
| PROVIDER: | scopus |
| PUBMED: | 24616252 |
| PMCID: | PMC4976502 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
