Clinical nodal stage is a significant predictor of outcome in patients with oral cavity squamous cell carcinoma and pathologically negative neck metastases: Results of the International Consortium for Outcome Research Journal Article
| Authors: | Amit, M.; Yen, T. C.; Liao, C. T.; Binenbaum, Y.; Chaturvedi, P.; Agarwal, J. P.; Kowalski, L. P.; Ebrahimi, A.; Clark, J. R.; Cernea, C. R.; Brandao, S. J.; Kreppel, M.; Zoller, J.; Fliss, D.; Bachar, G.; Shpitzer, T.; Bolzoni, V. A.; Patel, P. R.; Jonnalagadda, S.; Robbins, K. T.; Shah, J. P.; Patel, S. G.; Gil, Z.; The International Consortium for Outcome Research (ICOR) in Head and Neck Cancer |
| Article Title: | Clinical nodal stage is a significant predictor of outcome in patients with oral cavity squamous cell carcinoma and pathologically negative neck metastases: Results of the International Consortium for Outcome Research |
| Abstract: | Background: We aimed to study the importance of clinical N classification (cN) in a subgroup of patients with oral cavity squamous cell carcinoma (OSCC) and pathologically negative neck nodes (pN-). Methods: A total of 2,258 patients from 11 cancer centers who underwent neck dissection for OSCC (1990-2011) had pN- disease. The median follow-up was 44 months. 5-year overall survival (OS), disease-specific survival (DSS), disease free survival, local control, locoregional control, and distant metastasis rates were calculated by the Kaplan-Meier method. cN classification and tumor, node, metastasis classification system staging variables were subjected to multivariate analysis. Results: A total of 345 patients were preoperatively classified as cN+ and 1,913 were classified as cN-. The 5-year OS and DSS of cN- patients were 73.6 and 82.2 %, respectively. The 5-year OS and DSS of cN+ patients were 64.9 and 76.9 %, respectively (p < 0.0001 each). A cN+ classification was a significant predictor of worse OS (p = 0.03) and DSS (p = 0.016), regardless of treatment, depth of invasion, or extent of neck dissection. cN classification was associated with recurrence-free survival (p = 0.01) and locoregional (neck and primary tumor) control (p = 0.004), but not with local (p = 0.19) and distant (p = 0.06) recurrence rates. Conclusions: Clinical evidence of neck metastases is an independent predictor of outcome, even in patients with pN- nodes. © 2013 Society of Surgical Oncology. |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 20 |
| Issue: | 11 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2013-10-01 |
| Start Page: | 3575 |
| End Page: | 3581 |
| Language: | English |
| DOI: | 10.1245/s10434-013-3044-0 |
| PROVIDER: | scopus |
| PUBMED: | 23775408 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: ASONF" - "Source: Scopus" |
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