Survival outcomes after treatment of cancer of the oral cavity (1985–2015) Journal Article
| Authors: | Zanoni, D. K.; Montero, P. H.; Migliacci, J. C.; Shah, J. P.; Wong, R. J.; Ganly, I.; Patel, S. G. |
| Article Title: | Survival outcomes after treatment of cancer of the oral cavity (1985–2015) |
| Abstract: | Objectives: To present treatment results of oral squamous cell carcinoma (OSCC) at a tertiary cancer care center from 1985 to 2015. Materials and methods: A total of 2082 patients were eligible for this study. Main outcomes measured were overall survival (OS) and disease specific survival (DSS). Prognostic variables were identified with bivariate analyses using Kaplan-Meier curves and log-rank testing for comparison. A p-value < 0.05 was considered statistically significant and significant factors were entered into multivariate analysis. Median age was 62 years (16–100), 56% were men, 66% reported a history of tobacco use and 71% of alcohol consumption. The most common subsite was tongue (51%). Seventy-three percent of patients had cT1-2 and 71% had clinically negative necks (cN0). Surgery alone was performed in 1348 patients (65%), adjuvant postoperative radiotherapy in 608 patients (29%) and postoperative chemoradiation in 126 patients (6%). Neck dissection was performed in 920 patients with cN0, and in 585 patients with a clinically involved neck. The median follow-up was 37.6 months (range 1–382). Results: The 5-year OS and DSS were 64.4% and 79.3%, respectively. Age, comorbidities, margin status, vascular invasion, perineural invasion, AJCC 8th edition pT, and pN were independent prognostic factors of OS (p < 0.05). History of alcohol consumption, margin status, vascular invasion, perineural invasion, pT, and pN were independent prognostic factors of DSS (p < 0.05). Conclusion: pN stage is the most powerful and consistent predictor of outcome in patients with OSCC treated with primary surgery and appropriate adjuvant therapy. © 2019 Elsevier Ltd |
| Keywords: | squamous cell carcinoma; head and neck cancer; head and neck neoplasms; mouth neoplasms; mouth cancer; oral cancer; epidermoid carcinoma; oral neoplasms; upper aerodigestive tract neoplasms |
| Journal Title: | Oral Oncology |
| Volume: | 90 |
| ISSN: | 1368-8375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2019-03-01 |
| Start Page: | 115 |
| End Page: | 121 |
| Language: | English |
| DOI: | 10.1016/j.oraloncology.2019.02.001 |
| PROVIDER: | scopus |
| PMCID: | PMC6417804 |
| PUBMED: | 30846169 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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