Clinicopathologic characteristics of young patients with oral squamous cell carcinoma Journal Article


Authors: Mneimneh, W. S.; Xu, B.; Ghossein, C.; Alzumaili, B.; Sethi, S.; Ganly, I.; Khimraj, A.; Dogan, S.; Katabi, N.
Article Title: Clinicopathologic characteristics of young patients with oral squamous cell carcinoma
Abstract: Oral squamous cell carcinoma (OSCC) occasionally occurs in young patients and is likely to be distinct from OSCC in older patients. In this retrospective study, we described the clinicopathologic features and outcome of 150 OSCCs that were diagnosed in patients 40-year-old or younger. Most patients (63%) were non-smokers. The most common site of the primary tumor was oral tongue (n = 131, 87%), followed by gingiva (n = 9), buccal mucosa (n = 8) and lip (n = 2). The median patients' age at presentation was 34 (range: 16–40). Seven patients (5%) had Fanconi anemia with the gingiva being the most common location (4/7, 57%). All OSCCs were of keratinizing type. All cases tested for high-risk HPV (n = 34) were negative. On univariate analysis, high tumor budding was associated with decreased overall survival (OS) and distant metastasis free survival (DMFS), pattern of invasion correlated with OS and tumors with high stromal tumor infiltrating lymphocytes (sTIL) were associated with improved locoregional recurrence free survival (LRFS). Compared with patients 31 to 40-year-old, OSCC in the younger group was associated with significant less alcohol consumption (p = 0.011) and decreased DSS (p = 0.003) and DMFS (p = 0.023). On multivariate analysis, younger age (30 years or younger) was an independent prognostic factor for worse OS and DSS, whereas histologic grade was an independent prognostic factor for DSS. In summary, most OSCC in young patients occurred in non-smokers and did not occur in association with Fanconi anemia. Independent prognostic factors included age at presentation (30 years or younger) for OS and DSS, and histologic grade for DSS. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: squamous cell carcinoma; young patients; histologic grade
Journal Title: Head and Neck Pathology
Volume: 15
Issue: 4
ISSN: 1936-055X
Publisher: Humana Press Inc  
Date Published: 2021-12-01
Start Page: 1099
End Page: 1108
Language: English
DOI: 10.1007/s12105-021-01320-w
PROVIDER: scopus
PMCID: PMC8633158
PUBMED: 33797696
DOI/URL:
Notes: Article -- Export Date: 3 January 2022 -- Source: Scopus
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MSK Authors
  1. Nora Katabi
    258 Katabi
  2. Snjezana Dogan
    158 Dogan
  3. Ian Ganly
    352 Ganly
  4. Bin   Xu
    159 Xu
  5. Anjanie Khimraj
    12 Khimraj
  6. Shenon Sethi
    3 Sethi