Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23 Journal Article
| Authors: | Schumacher, F. R.; Wang, Z.; Skotheim, R. I.; Koster, R.; Chung, C. C.; Hildebrandt, M. A. T.; Kratz, C. P.; Bakken, A. C.; Timothy Bishop, D.; Cook, M. B.; Loren Erickson, R.; Fossa, S. D.; Greene, M. H.; Jacobs, K. B.; Kanetsky, P. A.; Kolonel, L. N.; Loud, J. T.; Korde, L. A.; Le Marchand, L.; Lewinger, J. P.; Lothe, R. A.; Pike, M. C.; Rahman, N.; Rubertone, M. V.; Schwartz, S. M.; Siegmund, K. D.; Skinner, E. C.; Turnbull, C.; Van Den Berg, D. J.; Wu, X.; Yeager, M.; Nathanson, K. L.; Chanock, S. J.; Cortessis, V. K.; McGlynn, K. A. |
| Article Title: | Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23 |
| Abstract: | Genome-wide association studies (GWASs) have identified multiple common genetic variants associated with an increased risk of testicular germ cell tumors (TGCTs). A previous GWAS reported a possible TGCT susceptibility locus on chromosome 1q23 in the UCK2 gene, but failed to reach genome-wide significance following replication. We interrogated this region by conducting a meta-analysis of two independent GWASs including a total of 940 TGCT cases and 1559 controls for 122 single-nucleotide polymorphisms (SNPs) on chromosome 1q23 and followed up the most significant SNPs in an additional 2202 TGCT cases and 2386 controls from four case-control studies. We observed genome-wide significant associations for several UCK2 markers, the most significant of which was for rs3790665 (PCombined = 6.0 x 10-9). Additional support is provided from an independent familial study of TGCT where a significant over-transmission for rs3790665 with TGCT risk was observed (PFBAT = 2.3 x 10-3). Here, we provide substantial evidence for the association between UCK2 genetic variation and TGCT risk. |
| Journal Title: | Human Molecular Genetics |
| Volume: | 22 |
| Issue: | 13 |
| ISSN: | 0964-6906 |
| Publisher: | Oxford University Press |
| Date Published: | 2013-07-01 |
| Start Page: | 2748 |
| End Page: | 2753 |
| Language: | English |
| DOI: | 10.1093/hmg/ddt109 |
| PROVIDER: | scopus |
| PMCID: | PMC3674801 |
| PUBMED: | 23462292 |
| DOI/URL: | |
| Notes: | --- - Cited By (since 1996):2 - "Export Date: 1 July 2013" - "CODEN: HMGEE" - "Source: Scopus" |
