Non-gaussian analysis of diffusion-weighted MR imaging in head and neck squamous cell carcinoma: A feasibility study Journal Article
| Authors: | Jansen, J. F. A.; Stambuk, H. E.; Koutcher, J. A.; Shukla-Dave, A. |
| Article Title: | Non-gaussian analysis of diffusion-weighted MR imaging in head and neck squamous cell carcinoma: A feasibility study |
| Abstract: | BACKGROUND AND PURPOSE: Water in biological structures often displays non-Gaussian diffusion behavior. The objective of this study was to test the feasibility of non-Gaussian fitting by using the kurtosis model of the signal intensity decay curves obtained from DWI by using an extended range of b-values in studies of phantoms and HNSCC. MATERIALS AND METHODS: Seventeen patients with HNSCC underwent DWI by using 6 b-factors (0, 50-1500 s/mm2) at 1.5T. Monoexponential (yielding ADCmono) and non-Gaussian kurtosis (yielding apparent diffusion coefficient Dapp and apparent kurtosis coefficient Kapp) fits were performed on a voxel-by-voxel basis in selected regions of interest (primary tumors, metastatic lymph nodes, and spinal cord). DWI studies were also performed on phantoms containing either water or homogenized asparagus. To determine whether the kurtosis model provided a significantly better fit than did the monoexponential model, an F test was performed. Spearman correlation coefficients were calculated to assess correlations between Kapp and Dapp. RESULTS: The kurtosis model fit the experimental data points significantly better than did the monoexponential model (P < .05). Dapp was approximately twice the value of ADCmono (eg, in neck nodal metastases Dapp was 1.54 and ADCmono was 0.84). Kapp showed a weak Spearman correlation with Dapp in a homogenized asparagus phantom and for 44% of tumor lesions. CONCLUSIONS: The use of kurtosis modeling to fit DWI data acquired by using an extended b-value range in HNSCC is feasible and yields a significantly better fit of the data than does monoexponential modeling. It also provides an additional parameter, Kapp, potentially with added value. |
| Keywords: | adult; clinical article; aged; aged, 80 and over; middle aged; squamous cell carcinoma; carcinoma, squamous cell; lymph node metastasis; lymphatic metastasis; retrospective study; algorithms; feasibility study; feasibility studies; spinal cord; phantom; water; phantoms, imaging; cervical lymph node; image processing, computer-assisted; gadolinium pentetate; image processing; software; diffusion weighted imaging; diffusion magnetic resonance imaging; normal distribution; head and neck carcinoma; nuclear magnetic resonance scanner; head and neck squamous cell carcinoma; asparagus; otorhinolaryngologic neoplasms |
| Journal Title: | American Journal of Neuroradiology |
| Volume: | 31 |
| Issue: | 4 |
| ISSN: | 0195-6108 |
| Publisher: | American Society of Neuroradiology |
| Date Published: | 2010-04-01 |
| Start Page: | 741 |
| End Page: | 748 |
| Language: | English |
| DOI: | 10.3174/ajnr.A1919 |
| PUBMED: | 20037133 |
| PROVIDER: | scopus |
| PMCID: | PMC2854270 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: AAJND" - "Source: Scopus" |
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