Diffusion-weighted MRI of the lung at 3T evaluated using echo-planar-based and single-shot turbo spin-echo-based acquisition techniques for radiotherapy applications Journal Article


Authors: Tyagi, N.; Cloutier, M.; Zakian, K.; Deasy, J. O.; Hunt, M.; Rimner, A.
Article Title: Diffusion-weighted MRI of the lung at 3T evaluated using echo-planar-based and single-shot turbo spin-echo-based acquisition techniques for radiotherapy applications
Abstract: Purpose: To compare single-shot echo-planar (SS-EPI)-based and turbo spin-echo (SS-TSE)-based diffusion-weighted imaging (DWI) in Non-Small Cell Lung Cancer (NSCLC) patients and to characterize the distributions of apparent diffusion coefficient (ADC) values generated by the two techniques. Methods: Ten NSCLC patients were enrolled in a prospective IRB-approved study to compare and optimize DWI using EPI and TSE-based techniques for radiotherapy planning. The imaging protocol included axial T2w, EPI-based DWI and TSE-based DWI on a 3 T Philips scanner. Both EPI-based and TSE-based DWI sequences used three b values (0, 400, and 800 s/mm2). The acquisition times for EPI-based and TSE-based DWI were 5 and 8 min, respectively. DW-MR images were manually coregistered with axial T2w images, and tumor volume contoured on T2w images were mapped onto the DWI scans. A pixel-by-pixel fit of tumor ADC was calculated based on monoexponential signal behavior. Tumor ADC mean, standard deviation, kurtosis, and skewness were calculated and compared between EPI and TSE-based DWI. Image distortion and ADC values between the two techniques were also quantified using fieldmap analysis and a NIST traceable ice-water diffusion phantom, respectively. Results: The mean ADC for EPI and TSE-based DWI were 1.282 ± 0.42 × 10−3 and 1.211 ± 0.31 × 10−3 mm2/s. The average skewness and kurtosis were 0.14 ± 0.4 and 2.43 ± 0.40 for DWI-EPI and −0.06 ± 0.69 and 2.89 ± 0.62 for DWI-TSE. Fieldmap analysis showed a mean distortion of 13.72 ± 8.12 mm for GTV for DWI-EPI and 0.61 ± 0.4 mm for DWI-TSE. ADC values obtained using the diffusion phantom for the two techniques were within 0.03 × 10−3 mm2/s with respect to each other as well as the established values. Conclusions: Diffusion-weighted turbo spin-echo shows better geometrical accuracy compared to DWI-EPI. Mean ADC values were similar with both acquisitions but the shape of the histograms was different based on the skewness and kurtosis values. The impact of differences in respiratory technique on ADC values requires further investigation. © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.
Keywords: non-small cell lung cancer; echo-planar imaging; dw-mri; turbo spin-echo
Journal Title: Journal of Applied Clinical Medical Physics
Volume: 20
Issue: 1
ISSN: 1526-9914
Publisher: American College of Medical Physics  
Date Published: 2019-01-01
Start Page: 284
End Page: 292
Language: English
DOI: 10.1002/acm2.12493
PUBMED: 30421496
PROVIDER: scopus
PMCID: PMC6333125
DOI/URL:
Notes: Article -- Export Date: 1 February 2019 -- Source: Scopus
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MSK Authors
  1. Andreas Rimner
    254 Rimner
  2. Kristen L Zakian
    74 Zakian
  3. Joseph Owen Deasy
    277 Deasy
  4. Margie A Hunt
    228 Hunt
  5. Neelam Tyagi
    54 Tyagi