Reduced-distortion diffusion weighted imaging for head and neck radiotherapy Journal Article
| Authors: | Aliotta, E.; Paudyal, R.; Dresner, A.; Shukla-Dave, A.; Lee, N.; Cerviño, L.; Otazo, R.; Yu, V. Y. |
| Article Title: | Reduced-distortion diffusion weighted imaging for head and neck radiotherapy |
| Abstract: | Background and purpose: Quantitative Diffusion Weighted Imaging (DWI) has potential value in guiding head and neck (HN) cancer radiotherapy. However, clinical translation has been hindered by severe distortions in standard single-shot Echo-Planar-Imaging (ssEPI) and prolonged scan time and low SNR in Turbo-Spin-Echo (ssTSE) sequences. In this study, we evaluate “multi-shot” (ms) msEPI and msTSE acquisitions in the context of HN radiotherapy. Materials and methods: ssEPI, ssTSE, msEPI with 2 and 3 shots (2sEPI, 3sEPI), and msTSE DWI were acquired in a phantom, healthy volunteers (N=10), and patients with HN cancer (N=5) on a 3-Tesla wide-bore MRI in radiotherapy simulation RF coil setup, with matched spatial resolution (2x2x5mm) and b = 0, 200, 800 s/mm2. Geometric distortions measured with deformable vector field (DVF) and contour analysis, apparent diffusion coefficient (ADC) values, and signal-to-noise-ratio efficiency (SNReff) were quantified for all scans. Results: All techniques significantly (P<1x10-3) reduced distortions compared with ssEPI (DVFmean = 3.1 ± 1.3 mm). Distortions were marginally lower for msTSE (DVFmean = 1.5 ± 0.6 mm) than ssTSE (1.8 ± 0.9 mm), but were slightly higher with 2sEPI and 3sEPI (2.6 ± 1.0 mm, 2.2 ± 1.0 mm). SNReff reduced with decreasing distortion with ssEPI=21.9 ± 7.9, 2sEPI=15.1 ± 5.0, 3sEPI=12.1 ± 4.5, ssTSE=6.0 ± 1.6, and msTSE=5.7 ± 1.9 for b = 0 images. Phantom ADC values were consistent across all protocols (errors ≤ 0.03x10-3mm2/s), but in vivo ADC values were ∼ 4 % lower with msEPI and ∼ 12 % lower with ssTSE/msTSE compared with ssEPI. Conclusions: msEPI and TSE acquisitions exhibited improved geometric distortion at the cost of SNReff and scan time. While msTSE exhibited the least distortion, 3sEPI may offer an appealing middle-ground with improved geometric fidelity but superior efficiency and in vivo ADC quantification. © 2024 The Authors |
| Keywords: | clinical article; controlled study; aged; cancer radiotherapy; comparative study; nuclear magnetic resonance imaging; outcome assessment; clinical assessment; signal noise ratio; in vivo study; head and neck cancer; geometry; spinal cord; clinical evaluation; diffusion weighted imaging; wart virus; apparent diffusion coefficient; human; male; female; article; povidone |
| Journal Title: | Physics and Imaging in Radiation Oncology |
| Volume: | 32 |
| ISSN: | 2405-6316 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2024-10-01 |
| Start Page: | 100653 |
| Language: | English |
| DOI: | 10.1016/j.phro.2024.100653 |
| PROVIDER: | scopus |
| PMCID: | PMC11466654 |
| PUBMED: | 39399877 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Eric Aliotta -- Source: Scopus |
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137Dave -
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47Otazo Torres -
135Cervino Arriba -
20Yu -
15Aliotta
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