A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle Conference Paper
| Authors: | De La Zerda, A.; Kircher, M. F.; Jokerst, J. V.; Zavaleta, C. L.; Kempen, P. J.; Mittra, E.; Pitter, K.; Huang, R.; Campos, C.; Habte, F.; Sinclair, R.; Brennan, C. W.; Mellinghoff, I. K.; Holland, E. C.; Gambhir, S. S. |
| Title: | A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle |
| Conference Title: | Photons Plus Ultrasound: Imaging and Sensing 2013 |
| Abstract: | The difficulty in delineating brain tumor margins is a major obstacle in the path toward better outcomes for patients with brain tumors. Current imaging methods are often limited by inadequate sensitivity, specificity and spatial resolution. Here we show that a unique triplemodality magnetic resonance imaging - photoacoustic imaging - Raman imaging nanoparticle (termed here MPR nanoparticles), can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively. The MPRs were detected by all three modalities with at least a picomolar sensitivity both in vitro and in living mice. Intravenous injection of MPRs into glioblastoma-bearing mice led to MPR accumulation and retention by the tumors, with no MPR accumulation in the surrounding healthy tissue, allowing for a noninvasive tumor delineation using all three modalities through the intact skull. Raman imaging allowed for guidance of intraoperative tumor resection, and a histological correlation validated that Raman imaging was accurately delineating the brain tumor margins. This new triple-modality-nanoparticle approach has promise for enabling more accurate brain tumor imaging and resection. © 2013 Copyright SPIE. |
| Keywords: | magnetic resonance imaging; molecular imaging; brain; tumors; nanoparticles; photons; mammals; ultrasonics; intravenous injections; tumor resection; spatial resolution; brain tumor imaging; healthy tissues; photo-acoustic imaging; picomolar sensitivity; tumor delineation |
| Journal Title | Proceedings of SPIE |
| Volume: | 8581 |
| Conference Dates: | 2013 Feb 3-5 |
| Conference Location: | San Francisco, CA |
| ISBN: | 0277-786X |
| Publisher: | SPIE |
| Location: | San Francisco, CA |
| Date Published: | 2013-01-01 |
| Start Page: | 85810G |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.1117/12.2001719 |
| DOI/URL: | |
| Notes: | --- - Progress in Biomedical Optics and Imaging - Proceedings of SPIE - Progr. Biomed. Opt. Imaging Proc. SPIE - "Conference code: 96986" - "Export Date: 1 July 2013" - ":doi 10.1117/12.2001719" - "Sponsors: The Society of Photo-Optical Instrumentation Engineers (SPIE)" - 3 February 2013 through 5 February 2013 - "Source: Scopus" |
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