Dual-modality surface-enhanced resonance Raman scattering and multispectral optoacoustic tomography nanoparticle approach for brain tumor delineation Journal Article

   

Authors:	Neuschmelting, V.; Harmsen, S.; Beziere, N.; Lockau, H.; Hsu, H. T.; Huang, R.; Razansky, D.; Ntziachristos, V.; Kircher, M. F.
Article Title:	Dual-modality surface-enhanced resonance Raman scattering and multispectral optoacoustic tomography nanoparticle approach for brain tumor delineation
Abstract:	Difficulty in visualizing glioma margins intraoperatively remains a major issue in the achievement of gross total tumor resection and, thus, better clinical outcome of glioblastoma (GBM) patients. Here, the potential of a new combined optical + optoacoustic imaging method for intraoperative brain tumor delineation is investigated. A strategy using a newly developed gold nanostar synthesis method, Raman reporter chemistry, and silication method to produce dual-modality contrast agents for combined surface-enhanced resonance Raman scattering (SERRS) and multispectral optoacoustic tomography (MSOT) imaging is devised. Following intravenous injection of the SERRS-MSOT-nanostars in brain tumor bearing mice, sequential MSOT imaging is performed in vivo and followed by Raman imaging. MSOT is able to accurately depict GBMs three-dimensionally with high specificity. The MSOT signal is found to correlate well with the SERRS images. Because SERRS enables uniquely sensitive high-resolution surface detection, it could represent an ideal complementary imaging modality to MSOT, which enables real-time, deep tissue imaging in 3D. This dual-modality SERRS-MSOT-nanostar contrast agent reported here is shown to enable high precision depiction of the extent of infiltrating GBMs by Raman- and MSOT imaging in a clinically relevant murine GBM model and could pave new ways for improved image-guided resection of brain tumors. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords:	image enhancement; brain; tomography; tumors; glioblastoma; medical nanotechnology; nanomedicine; neurooncology; resonance; glioblastomas; neuro-oncology; raman spectroscopy; photo-acoustic imaging; photoacoustic imaging; photoacoustic effect; raman scattering; surface scattering; multispectral optoacoustic tomography (msot); surface-enhanced resonance raman spectroscopy (serrs); photoacoustic spectroscopy; optoacoustic tomography; surface-enhanced resonance raman spectroscopies
Journal Title:	Small
Volume:	14
Issue:	23
ISSN:	1613-6810
Publisher:	Wiley V C H Verlag Gmbh
Date Published:	2018-06-07
Start Page:	1800740
Language:	English
DOI:	10.1002/smll.201800740
PROVIDER:	scopus
PUBMED:	29726109
PMCID:	PMC6541212
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046344823&doi=10.1002%2fsmll.201800740&partnerID=40&md5=f2d62c22b8c5cd64e76b844aeac50617
Notes:	Article -- Export Date: 2 July 2018 -- Source: Scopus

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