Prevalence of vitamin D insufficiency in survivors of childhood cancer Journal Article
| Authors: | Choudhary, A.; Chou, J.; Heller, G.; Sklar, C. |
| Article Title: | Prevalence of vitamin D insufficiency in survivors of childhood cancer |
| Abstract: | Background: Data on 25-hydroxyvitamin D (25-OH D) status among survivors of childhood cancer are limited. Our aim was to determine the prevalence of and risk factors for 25-OH D insufficiency in a large, diverse population of cancer survivors being followed in a childhood cancer survivor clinic. Procedure: Retrospective chart review in survivors seen for routine long-term follow-up, who underwent routine screening blood studies including 25-OH D levels. Vitamin D insufficiency was defined as 25-OH D <20ng/ml. Results: Four hundred eighty-four subjects (234 males) were evaluable for this analysis. Median age at 25-OH D testing was 12.3 years (2.05-36.4) and median age at cancer diagnosis was 3.9 years (0-18). Diagnoses included brain tumors (23.6%), neuroblastoma (21%), and leukemia (17.6%). Mean 25-OH D level was 25.2ng/ml (SD=10.37); 29% of subjects were 25-OH D insufficient. In univariate analysis, race, pubertal status, and age at cancer diagnosis were associated with 25-OH D insufficiency (P<0.05). In multivariate analysis, a model including race and pubertal status provided a good fit for the data. Conclusions: The prevalence of 25-OH D insufficiency in these cancer survivors was high but similar to what has been described in the general population. No cancer specific variables were associated with 25-OH D insufficiency. Since cancer survivors are at a higher risk for subsequent malignancies, cardiovascular disease, and low bone mineral density, all of which may be affected by 25-OH D levels, interventions to improve 25-OH D status in this vulnerable population are needed. © 2012 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; child; controlled study; preschool child; school child; major clinical study; follow up; disease association; prevalence; medical record review; retrospective study; risk factor; childhood cancer; cancer survivor; neuroblastoma; vitamin d; brain cancer; vitamin d deficiency; childhood leukemia; cancer survivors; 25 hydroxyvitamin d |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 60 |
| Issue: | 7 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2013-07-01 |
| Start Page: | 1237 |
| End Page: | 1239 |
| Language: | English |
| DOI: | 10.1002/pbc.24403 |
| PROVIDER: | scopus |
| PUBMED: | 23192881 |
| PMCID: | PMC4006112 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 July 2013" - "CODEN: PBCEA" - "Source: Scopus" |
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