Pharmacology of aging and cancer: How useful are pharmacokinetic tests? Book Section
| Author: | Lichtman, Stuart M. |
| Editor: | Extermann, M. |
| Article/Chapter Title: | Pharmacology of aging and cancer: How useful are pharmacokinetic tests? |
| Title Series: | Interdisciplinary Topics in Gerontology |
| Abstract: | The elderly comprise the majority of patients with cancer and are the recipients of the greatest amount of chemotherapy. Unfortunately, there is a lack of data to make evidence-based decisions with regard to chemotherapy. This is due to the minimal participation of older patients in clinical trials and that trials have not systematically evaluated chemotherapy. This chapter reviews the available information with regard to chemotherapy and aging. Due to the lack of prospective data, the conclusions and recommendations made are a consensus of the available information. Extrapolation of data from younger to older patients is necessary, particularly to those patients older than 80 years, for which data is almost entirely lacking. The classes of drugs reviewed include alkylators, antimetabolites, platinum compounds, anthracyclines, taxanes, purine analogues, antimicrotubule agents, camptothecins, and epipodophyllotoxins. Clinical trials need to incorporate an analysis of chemotherapy in terms of the pharmacokinetic and pharmacodynamic effects of aging. In addition, data already accumulated need to be re-analyzed by age to aid in the management of the older cancer patient. Copyright (C) 2013 S. Karger AG, Basel |
| Keywords: | pharmacodynamics; pharmacokinetics; human medicine; medical sciences; 10060; biochemistry studies - general 12512; pharmacology - general 22005; neoplasms - pathology; clinical aspects and systemic effects 24008; chemotherapy therapeutic and prophylactic techniques; pharmacology - clinical pharmacology 24004; pathology - therapy 22002; enzyme inhibitor-drug; pharmacology oncology; aging geriatrics; neoplasms - therapeutic agents and therapy 24500; gerontology camptothecin 7689-03-4 antineoplastic-drug; /anthracycline antineoplastic-drug; /taxane 1605-68-1 antineoplastic-drug; /alkylator antineoplastic-drug; /antimetabolite antineoplastic-drug; /platinum compound antineoplastic-drug; /purine analogue antineoplastic-drug; /antimicrotubule agent antineoplastic-drug; /epipodophyllotoxin 4375-07-9 antineoplastic-drug; clinical techniques/pharmacokinetic test laboratory techniques aging |
| Book Title: | Cancer and Aging: From Bench to Clinics |
| Volume: | 38 |
| ISBN: | 978-3-318-02306-0 |
| Publisher: | S. Karger AG |
| Publication Place: | Basel, Switzerland |
| Date Published: | 2013-01-01 |
| Start Page: | 104 |
| End Page: | 123 |
| Language: | English |
| DOI: | 10.1159/000343618 |
| ACCESSION: | BIOSIS:PREV201300353356 |
| PROVIDER: | biosis |
| PUBMED: | 23503519 |
| Notes: | --- - Book Chapter - Postfach, ch-4009 basel, switzerland - "Source: Biosis" |
