Chemotherapy options and outcomes in older adult patients with colorectal cancer Journal Article
| Authors: | Saif, M. W.; Lichtman, S. M. |
| Article Title: | Chemotherapy options and outcomes in older adult patients with colorectal cancer |
| Abstract: | The majority of patients with colorectal cancer (CRC) are ≥65 years of age, yet older patients with CRC remain under-represented in clinical trials. Older adult patients may be more likely than younger patients to experience chemotherapy-related toxicities due to factors such as existing comorbidities, incompatibility of chemotherapy with other medications, and age-related reduction in the detoxification and elimination potential of the liver and kidneys. However, the older patient group are a heterogeneous population. The available data on treatment of older patients with CRC indicate that fit older adult patients have the potential to derive the same benefit as do younger patients. A comprehensive geriatric assessment can help to identify patients most likely to benefit from standard treatment. In this review, we will evaluate the chemotherapy regimens investigated in older adult patients with CRC, and how the safety profiles and efficacy of chemotherapy in the older adult compare with those observed in younger patients. © 2009 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | cancer chemotherapy; treatment outcome; aged; clinical trial; fatigue; neutropenia; review; bevacizumab; erlotinib; fluorouracil; advanced cancer; cancer combination chemotherapy; diarrhea; drug dose reduction; drug efficacy; drug safety; drug withdrawal; gastrointestinal hemorrhage; hypertension; patient selection; risk benefit analysis; skin toxicity; unspecified side effect; antineoplastic agents; clinical trials as topic; drug targeting; capecitabine; adjuvant therapy; cancer adjuvant therapy; chemotherapy; neurotoxicity; colorectal cancer; treatment indication; bolus injection; low drug dose; metastasis; quality of life; infection; liver toxicity; multiple cycle treatment; sensory neuropathy; anemia; bone marrow suppression; leukopenia; mucosa inflammation; neuropathy; stomatitis; thrombocytopenia; dehydration; peripheral neuropathy; practice guideline; age factors; continuous infusion; vasculotropin inhibitor; cetuximab; irinotecan; panitumumab; asthenia; febrile neutropenia; colorectal neoplasms; gastrointestinal toxicity; liver metastasis; drug antagonism; drug mechanism; thromboembolism; folinic acid; cardiotoxicity; comorbidity; gefitinib; warfarin; patient compliance; nausea and vomiting; liver resection; aging; detoxification; sensory dysfunction; drug half life; biological therapy; toxicity; drug substitution; oxaliplatin; hand foot syndrome; lethargy; frail elderly; functional status; geriatric assessment; epidermal growth factor receptor kinase inhibitor; anticoagulant agent; older adult; quinapril; tegafur; acute psychosis; drug elimination |
| Journal Title: | Critical Reviews in Oncology/Hematology |
| Volume: | 72 |
| Issue: | 2 |
| ISSN: | 1040-8428 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2009-11-01 |
| Start Page: | 155 |
| End Page: | 169 |
| Language: | English |
| DOI: | 10.1016/j.critrevonc.2009.02.006 |
| PUBMED: | 19356946 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: CCRHE" - "Source: Scopus" |
