Oral single-agent chemotherapy in older patients with solid tumours: A position paper from the International Society of Geriatric Oncology (SIOG) Journal Article
| Authors: | Biganzoli, L.; Lichtman, S.; Michel, J. P.; Papamichael, D.; Quoix, E.; Walko, C.; Aapro, M. |
| Article Title: | Oral single-agent chemotherapy in older patients with solid tumours: A position paper from the International Society of Geriatric Oncology (SIOG) |
| Abstract: | Compared with intravenous (i.v.) chemotherapy, oral administration is convenient, requires fewer healthcare resources, is generally preferred by patients, and may be appropriate in older people with breast, colorectal and lung cancers. The effects of organ dysfunction on drug metabolism and drug interactions in patients with multiple comorbidities must be considered but are not specific to oral chemotherapy. Single-agent oral chemotherapy with capecitabine or vinorelbine is active in older patients with advanced or metastatic breast cancer. Choice of treatment is based mainly on different safety profiles. In the adjuvant treatment of colorectal cancer (CRC), single-agent oral capecitabine is an effective alternative to i.v. fluorouracil (5-FU) regimens. In metastatic CRC, oral, single-agent capecitabine has recently shown encouraging median overall survival in combination with bevacizumab. In non-small cell lung cancer, fit older patients, like their younger counterparts, benefit from platinum-based doublets, with carboplatin preferred to cisplatin. Single agent vinorelbine is an option for those less suited to combination chemotherapy, and oral may be an alternative to i.v. administration. For elderly cancer patients in general, metronomic chemotherapy combines good tolerability with acceptable activity. © 2015 Elsevier Ltd. |
| Keywords: | cancer chemotherapy; overall survival; drug tolerability; review; bevacizumab; cisplatin; fluorouracil; advanced cancer; cancer combination chemotherapy; drug efficacy; drug safety; solid tumor; capecitabine; cancer adjuvant therapy; cancer patient; antineoplastic agent; colorectal cancer; carboplatin; breast cancer; lung cancer; antineoplastic activity; age; comorbidity; medical society; patient compliance; platinum; navelbine; breast metastasis; non small cell lung cancer; patient preference; older patients; metastatic colorectal cancer; oral chemotherapy; vinorelbine; metronomic drug administration; human; priority journal; metronomic therapy |
| Journal Title: | European Journal of Cancer |
| Volume: | 51 |
| Issue: | 17 |
| ISSN: | 0959-8049 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-11-01 |
| Start Page: | 2491 |
| End Page: | 2500 |
| Language: | English |
| DOI: | 10.1016/j.ejca.2015.08.005 |
| PROVIDER: | scopus |
| PUBMED: | 26340809 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 7 January 2016 -- 2491 -- Source: Scopus |
