Hepatocellular carcinoma in older adults: A comprehensive review by Young International Society of Geriatric Oncology Journal Article


Authors: Arora, S. P.; Liposits, G.; Caird, S.; Dunne, R. F.; Moffat, G. T.; Okonji, D.; Rodriquenz, M. G.; Dua, D.; Dotan, E.
Article Title: Hepatocellular carcinoma in older adults: A comprehensive review by Young International Society of Geriatric Oncology
Abstract: Given the prevalence and the rising incidence of hepatocellular carcinoma (HCC) in older adults worldwide, there is an urgent need to improve our understanding of the implications of treatment modalities in this population. The care of older patients with HCC is challenging due to the lack of evidence-based recommendations in this population. The current treatment approach for older patients relies on extrapolation of data from clinical trials conducted mostly in younger patients or fit older adults. Further, in the last few years, the arsenal of systemic treatments has increased with currently seven FDA-approved therapies available for patients with advanced HCC. Therefore, understanding how to apply current data to this unique and diverse patient population is necessary. This review will aim to shed light on the approach to older adults with HCC through an assessment of available data in the literature. © 2019 Elsevier Inc.
Keywords: drug tolerability; fatigue; review; hepatocellular carcinoma; sorafenib; placebo; chemoembolization; diarrhea; drug dose reduction; drug efficacy; drug safety; drug withdrawal; hypertension; liver cell carcinoma; liver transplantation; side effect; systemic therapy; drug targeting; cancer incidence; anorexia; cancer immunotherapy; nausea; prevalence; drug dose escalation; postoperative complication; graft failure; drug response; patient safety; medical society; peripheral edema; erythema; liver resection; therapy effect; radiofrequency ablation; stereotactic body radiation therapy; hand foot syndrome; elderly care; geriatric assessment; older adult; decreased appetite; tumor ablation; hypertransaminasemia; multimodality treatment; body weight loss; frailty; voice change; cabozantinib; nivolumab; regorafenib; lenvatinib; ramucirumab; human; priority journal; pembrolizumab; selective internal radiation therapy; microwave thermotherapy
Journal Title: Journal of Geriatric Oncology
Volume: 11
Issue: 4
ISSN: 1879-4068
Publisher: Elsevier Inc.  
Date Published: 2020-05-01
Start Page: 557
End Page: 565
Language: English
DOI: 10.1016/j.jgo.2019.10.007
PUBMED: 31704038
PROVIDER: scopus
PMCID: PMC7188597
DOI/URL:
Notes: Review -- Source: Scopus
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  1. Gordon Taylor Moffat
    5 Moffat