Combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma Journal Article


Authors: Connell, L. C.; Harding, J. J.; Shia, J.; Abou-Alfa, G. K.
Article Title: Combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma
Abstract: Hepatocellular carcinoma (HCC), the fifth most common cancer globally and third leading cause of cancer-related mortality is a heterogeneous disease with a highly variable clinical course. The inherent biological diversity of hepatic carcinomas may hinder therapeutic decision making and prognostication for patients. One distinct, albeit rare, subtype of primary hepatic carcinoma is combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma (cHCC-ICC), which carries an overall worse prognosis than either HCC or intrahepatic cholangiocarcinoma (ICC) alone. cHCC-ICC is a primary hepatic neoplasm containing unequivocal elements of both HCC and ICC. This review will focus on understanding further the histopathology of this unique tumor type, current treatment approaches and prognoses for this rare patient population. © Chinese Clinical Oncology. All rights reserved.
Keywords: needle biopsy; surgical resection; prognosis; combined intrahepatic cholangiocarcinoma and hepatocellular carcinoma (chcc-icc)
Journal Title: Chinese Clinical Oncology
Volume: 5
Issue: 5
ISSN: 2304-3865
Publisher: AME Publishing Company  
Date Published: 2016-10-01
Start Page: 66
Language: English
DOI: 10.21037/cco.2016.10.02
PROVIDER: scopus
PUBMED: 27829279
DOI/URL:
Notes: Review -- Export Date: 3 January 2017 -- Source: Scopus
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  1. James Joseph Harding
    250 Harding
  2. Ghassan Abou-Alfa
    568 Abou-Alfa
  3. Jinru Shia
    717 Shia
  4. Louise Catherine Connell
    45 Connell