The primary cilium: A signalling centre during vertebrate development Journal Article

   


Authors: Goetz, S. C.; Anderson, K. V.
Article Title: The primary cilium: A signalling centre during vertebrate development
Abstract: The primary cilium has recently stepped into the spotlight, as a flood of data show that this organelle has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for hedgehog signal transduction. The formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The cilium therefore represents a nexus for signalling pathways during development. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. © 2010 Macmillan Publishers Limited. All rights reserved.
Keywords: signal transduction; unclassified drug; review; nonhuman; mutant protein; animals; sonic hedgehog protein; hedgehog proteins; protein; embryo development; intracellular transport; vertebrata; gene disruption; fibroblast; cell polarity; development; genetic disorder; ubiquitin protein ligase e3; erinaceidae; vertebrate; vertebrates; membrane transport; eukaryotic flagellum; cilia; kinesin; dynein adenosine triphosphatase; guanosine triphosphatase; basal body protein; centrosomal protein; chaperonin like protein; cytoplasmic dynein 2 heavy chain 1; cytoplasmic dynein 2 light intermediate chain 1; ellis van creveld syndrome protein; gli transcription factor; meckel syndrome type 1 protein
Journal Title: Nature Reviews Genetics
Volume: 11
Issue: 5
ISSN: 1471-0056
Publisher: Nature Publishing Group  
Date Published: 2010-05-01
Start Page: 331
End Page: 344
Language: English
DOI: 10.1038/nrg2774
PUBMED: 20395968
PROVIDER: scopus
PMCID: PMC3121168
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77951101203&partnerID=40&md5=29dba824ca7c55c893b2984331556406
Notes: --- - "Cited By (since 1996): 27" - "Export Date: 20 April 2011" - "CODEN: NRGAA" - "Source: Scopus"
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MSK Authors
  1. Sarah C Goetz
    6 Goetz
  2. Kathryn Anderson
    148 Anderson
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