Cilia and developmental signaling Journal Article


Authors: Eggenschwiler, J. T.; Anderson, K. V.
Article Title: Cilia and developmental signaling
Abstract: Recent studies have revealed unexpected connections between the mammalian Hedgehog (Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that protrudes from the surface of most vertebrate cells. Intraflagellar transport proteins, which are required for the construction of cilia, are essential for all responses to mammalian Hh proteins, and proteins required for Hh signal transduction are enriched in primary cilia. The phenotypes of different mouse mutants that affect ciliary proteins suggest that cilia may act as processive machines that organize sequential steps in the Hh signal transduction pathway. Cilia on vertebrate cells are likely to be important in additional developmental signaling pathways and are required for PDGF receptor α signaling in cultured fibroblasts. Cilia are not essential for either canonical or noncanonical Wnt signaling, although cell-type-specific modulation of cilia components may link cilia and Wnt signaling in some tissues. Because ciliogenesis in invertebrates is limited to a very small number of specialized cell types, the role of cilia in developmental signaling pathways is likely a uniquely vertebrate phenomenon. Copyright © 2007 by Annual Reviews. All rights reserved.
Keywords: signal transduction; carrier protein; genetics; review; nonhuman; protein function; mouse; phenotype; animal; metabolism; mammalia; animals; mice; platelet derived growth factor alpha receptor; sonic hedgehog protein; hedgehog proteins; morphogenesis; physiology; vertebrata; growth, development and aging; protein transport; fibroblast; development; genetic disorder; wnt protein; erinaceidae; vertebrate; eukaryotic flagellum; body patterning; cilia; neural tube; intraflagellar transport; wnt; invertebrata; hedgehog; pdgfrα; genetic diseases, inborn
Journal Title: Annual Review of Cell and Developmental Biology
Volume: 23
ISSN: 1081-0706
Publisher: Annual Reviews  
Date Published: 2007-11-01
Start Page: 345
End Page: 373
Language: English
DOI: 10.1146/annurev.cellbio.23.090506.123249
PUBMED: 17506691
PROVIDER: scopus
PMCID: PMC2094042
DOI/URL:
Notes: --- - "Cited By (since 1996): 151" - "Export Date: 17 November 2011" - "CODEN: ARDBF" - "Source: Scopus"
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  1. Kathryn Anderson
    142 Anderson