CD30+ lymphomatoid drug reactions Journal Article
| Authors: | Pulitzer, M. P.; Nolan, K. A.; Oshman, R. G.; Phelps, R. G. |
| Article Title: | CD30+ lymphomatoid drug reactions |
| Abstract: | We report 5 cases of cutaneous CD30+ lymphomatoid drug reactions that occurred shortly after the onset of drug exposure and resolved promptly upon withdrawal of the offending agents. The cases showed protean dermatologic manifestations ranging from diffuse erythema with desquamation to macules, papules, and annular plaques. The suspect drugs were amlodipine (a calcium channel blocker) for 2 cases, sertraline (a selective serotonin reuptake inhibitor) for 1 case, gabapentin for 1 case, and levofloxacin (a fluoroquinolone) versus cefepime (a fourth generation cephalosporin), and metoprolol (a beta blocker), in the fifth case. The histopathologic findings included varying combinations of spongiotic dermatitis, lichenoid infiltrates, and interface dermatitis with a dermal infiltrate of large atypical lymphocytes. Three of the 5 cases contained as much as 30% CD30+ staining of all lymphocytes, whereas the remaining 2 showed 5%-15% positivity. Three patients had a history of allergy or immune dysregulation. Increased knowledge of CD30 positivity in lymphomatoid drug reactions may be relevant in an era of targeted drug therapies. Recognition of these findings may help clinicians to tailor appropriate clinical evaluation and treatment including a review of medications and the removal of possible offending agents. Copyright © 2013 by Lippincott Williams & Wilkins. |
| Keywords: | immunohistochemistry; adult; human tissue; aged; aged, 80 and over; middle aged; prednisone; histopathology; case report; drug withdrawal; biological markers; allergy; olanzapine; furosemide; biopsy; skin; salbutamol; amines; anti-bacterial agents; drug mechanism; gamma-aminobutyric acid; warfarin; predictive value of tests; erythema; metoprolol; papule; dermatitis; spironolactone; tacrolimus; levofloxacin; lymphocyte; lymphocytes; atenolol; glibenclamide; clonazepam; fluoxetine; sertraline; anticonvulsants; ofloxacin; drug eruptions; desquamation; carbamazepine; gabapentin; cd30 antigen; lymphoproliferative disorders; medical history; cyclohexanecarboxylic acids; docusate sodium; cefepime; trazodone; amlodipine; enalapril; pseudolymphoma; serotonin uptake inhibitors; immune dysregulation; montelukast; adrenergic beta-antagonists; antigens, cd30; calcium channel blockers; lymphoproliferative disorder; beclometasone dipropionate; salmeterol |
| Journal Title: | American Journal of Dermatopathology |
| Volume: | 35 |
| Issue: | 3 |
| ISSN: | 0193-1091 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2013-05-01 |
| Start Page: | 343 |
| End Page: | 350 |
| Language: | English |
| DOI: | 10.1097/DAD.0b013e31826bc1e5 |
| PROVIDER: | scopus |
| PUBMED: | 23328787 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 June 2013" - "CODEN: AJDOD" - "Source: Scopus" |
