ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia Journal Article
| Authors: | Liu, Ting; He, Mai; Carlson, D.; Hedvat, C.; Teruya-Feldstein, J. |
| Article Title: | ALK-positive anaplastic large cell lymphoma in a patient with chronic lymphocytic leukemia |
| Abstract: | This article reports the case of a 59-year-old patient with an 8-year history of chronic lymphocytic leukemia (CLL), prostate carcinoma, and squamous cell carcinoma who developed an ALK-positive anaplastic large cell lymphoma (ALCL). Lymph node and bone marrow biopsies showed 2 distinct morphologic populations: (a) the CLL component showing a diffuse monomorphous infiltrate of small lymphocytes with the typical immunophenotype showing positive CD20, CD5, CD23, and κ light chain restriction and (b) the ALCL component showing large anaplastic pleomorphic cells positive for CD30, CD45, ALK, CD45Ro, CD4, and vimentin. Polymerase chain reaction performed on the lymph node for immunoglobulin heavy chain and T-cell receptor γ and β showed gene rearrangements after macrodissection of morphologically distinct populations, indicating confirmed genetically distinct populations. Despite intensive chemotherapy, the patient died. This case represents the rare occurrence of an ALK-positive ALCL developing in a patient with CLL. © The Author(s) 2010. |
| Keywords: | immunohistochemistry; adult; middle aged; unclassified drug; fludarabine; prednisone; case report; squamous cell carcinoma; doxorubicin; cancer combination chemotherapy; rituximab; positron emission tomography; lymph nodes; bone marrow cells; carboplatin; reverse transcription polymerase chain reaction; computer assisted tomography; etoposide; antineoplastic combined chemotherapy protocols; cytogenetics; cyclophosphamide; vincristine; tumor antigen; ifosfamide; cancer hormone therapy; fever; gleason score; cd20 antigen; t lymphocyte receptor beta chain; t lymphocyte receptor gamma chain; immunoglobulin heavy chain; gene rearrangement; bone marrow biopsy; dna, neoplasm; hypermetabolism; consultation; protein-tyrosine kinases; large cell lymphoma; blood cell count; cd4 antigen; fatal outcome; chronic lymphatic leukemia; immunoglobulin kappa chain; cd5 antigen; leukocytosis; neoplasms, multiple primary; lymph node biopsy; lymphadenopathy; leukemia, lymphocytic, chronic, b-cell; cd45 antigen; chlorambucil; pentostatin; prostate carcinoma; cd30 antigen; vimentin; gene rearrangement, t-lymphocyte; chronic lymphocytic leukemia; composite; cd45ro antigen; lymphoma, large-cell, anaplastic; anaplastic large cell lymphoma; synchronous lymphoma; alk antigen; cd23 antigen |
| Journal Title: | International Journal of Surgical Pathology |
| Volume: | 18 |
| Issue: | 5 |
| ISSN: | 1066-8969 |
| Publisher: | Sage Publications |
| Date Published: | 2010-10-01 |
| Start Page: | 424 |
| End Page: | 428 |
| Language: | English |
| DOI: | 10.1177/1066896908324259 |
| PUBMED: | 18794171 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: IJSPF" - "Source: Scopus" |
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