CD30-positive lymphoproliferative disorders arising after regional therapy for recurrent melanoma: A report of two cases and analysis of CD30 expression Journal Article

  

Authors:	Gill, K.; Ariyan, C.; Wang, X.; Brady, M. S.; Pulitzer, M.
Article Title:	CD30-positive lymphoproliferative disorders arising after regional therapy for recurrent melanoma: A report of two cases and analysis of CD30 expression
Abstract:	Background and Objectives: Primary cutaneous CD30-positive T-cell lymphoproliferative disorders (CD30+ LPD), including primary cutaneous anaplastic large cell lymphoma (CALCL) and lymphomatoid papulosis (LyP), comprise the second most common group of cutaneous T-cell lymphomas (CTCL). The etiology of these disorders is not known. Isolated limb perfusion (ILP) and isolated limb infusion (ILI) are forms of regional chemotherapy used to treat recurrent tumors of the extremity, most commonly, melanoma. Secondary malignancy following regional therapy is rarely reported. Methods/Results: We identified two cases of CD30+ LPD arising in the affected limbs of patients treated with ILP/ILI. We subsequently performed CD30 immunohistochemical stains on 11 pre- and post-treatment skin specimens from melanoma patients treated with ILP/ILI and found that 5 of the 11 cases showed an increase in CD30+ lymphocytes following ILP/ILI. Conclusions: We hypothesize that ILP/ILI causes upregulation of CD30 expression in the extremities of treated patients, and suggest that this may be a marker of treatment response. However, a rare but long-term effect may be an increased risk of T-cell cutaneous lymphoproliferative disease in the affected limb. © 2014 Wiley Periodicals, Inc.
Keywords:	immunohistochemistry; adult; cancer chemotherapy; clinical article; human tissue; aged; middle aged; cancer surgery; histopathology; cancer recurrence; lymph node dissection; cancer grading; antigen expression; melanoma; pain; bleeding; melphalan; medical record review; retrospective study; lymphedema; dactinomycin; erythema; lymphoproliferative disease; upregulation; cellulitis; cd30 antigen; swelling; wide excision; isolated limb perfusion; limb perfusion; lymphomatoid papulosis; split thickness skin graft; very elderly; human; male; female; priority journal; article; lymphoma primary cutaneous anaplastic large-cell lymphoma; hyperthermic isolated limb perfusion; isolation perfusion
Journal Title:	Journal of Surgical Oncology
Volume:	110
Issue:	3
ISSN:	0022-4790
Publisher:	Wiley Blackwell
Date Published:	2014-09-01
Start Page:	258
End Page:	264
Language:	English
DOI:	10.1002/jso.23636
PROVIDER:	scopus
PUBMED:	24891295
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84905497587&partnerID=40&md5=8958219835cb2a510a5cafc2f60e5c57
Notes:	Export Date: 2 September 2014 -- CODEN: JSONA -- Source: Scopus

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