Chemical space, high throughput screening and the world of blockbuster drugs Journal Article
| Author: | Djaballah, H. |
| Article Title: | Chemical space, high throughput screening and the world of blockbuster drugs |
| Abstract: | We are constantly told that if a high throughput screen does not identify hit(s) then blame it on the compounds in your library. The community has accepted this notion and unleashed a chemical space exploration through the use of novel or pre-existing synthetic chemistries to supposedly generate better ones. Its efforts, unfortunately, did not result in a giant step for mankind to combat disease, rather this article would argue that we are still at the same start-up line as we were 30 years ago and should perhaps listen to the call of nature to revive natural product research as it has amassed the most diverse libraries over the past millions of years. |
| Journal Title: | Drug Discovery World |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 1469-4344 |
| Publisher: | RJ Communications and Media Ltd. |
| Date Published: | 2013-01-01 |
| Start Page: | 73 |
| End Page: | 78 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 June 2013" - "Source: Scopus" |
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101Djaballah
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