The SUMO pathway: Emerging mechanisms that shape specificity, conjugation and recognition Journal Article
| Authors: | Gareau, J. R.; Lima, C. D. |
| Article Title: | The SUMO pathway: Emerging mechanisms that shape specificity, conjugation and recognition |
| Abstract: | Proteins of the small ubiquitin-related modifier (SUMO) family are conjugated to proteins to regulate such cellular processes as nuclear transport, transcription, chromosome segregation and DNA repair. Recently, numerous insights into regulatory mechanisms of the SUMO modification pathway have emerged. Although SUMO-conjugating enzymes can discriminate between SUMO targets, many substrates possess characteristics that facilitate their modification. Other post-translational modifications also regulate SUMO conjugation, suggesting that SUMO signalling is integrated with other signal transduction pathways. A better understanding of SUMO regulatory mechanisms will lead to improved approaches for analysing the function of SUMO and substrate conjugation in distinct cellular pathways. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; protein phosphorylation; unclassified drug; review; nonhuman; ubiquitin; protein conformation; protein function; protein motif; protein analysis; animals; models, biological; protein binding; enzyme activity; protein processing; regulatory mechanism; amino acid sequence; substrate specificity; models, molecular; ubiquitin protein ligase e3; enzyme specificity; sumo protein; sumoylation; sumo-1 protein; protein interaction domains and motifs; small ubiquitin-related modifier proteins; ubiquitin conjugating enzyme; conjugation; sumo 1 protein; sumo 2 protein; sumo 3 protein; sumo 4 protein; ubiquitin conjugating enzyme e2 |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 11 |
| Issue: | 12 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-12-01 |
| Start Page: | 861 |
| End Page: | 871 |
| Language: | English |
| DOI: | 10.1038/nrm3011 |
| PUBMED: | 21102611 |
| PROVIDER: | scopus |
| PMCID: | PMC3079294 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: NRMCB" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work