Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways Journal Article
| Authors: | Capili, A. D.; Lima, C. D. |
| Article Title: | Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways |
| Abstract: | Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process. © 2007 Elsevier Ltd. All rights reserved. |
| Keywords: | unclassified drug; review; ubiquitin; protein conformation; enzyme activation; molecular mechanics; enzyme regulation; models, molecular; protein structure; glycoprotein; protein modification; conjugation; ubiquitin like protein; glycoprotein e1; glycoprotein e2; glycoprotein e3 |
| Journal Title: | Current Opinion in Structural Biology |
| Volume: | 17 |
| Issue: | 6 |
| ISSN: | 0959-440X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-12-01 |
| Start Page: | 726 |
| End Page: | 735 |
| Language: | English |
| DOI: | 10.1016/j.sbi.2007.08.018 |
| PUBMED: | 17919899 |
| PROVIDER: | scopus |
| PMCID: | PMC2174906 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 17 November 2011" - "CODEN: COSBE" - "Source: Scopus" |
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